Cristina Longo
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PhD
2018
, Médecine de famille , Université McGill (Canada)
MSc
2011
, Médecine de famille , Université McGill (Canada)
Postdoc
2021
, Épidémiologie et biostatistique , Université de Montréal (Canada), Amsterdam University Medical Center (Pays-Bas)
Biographie
Cristina Longo est épidémiologiste périnatale/pédiatrique, chercheuse en début de carrière au Centre de recherche du CHU Ste Justine et professeure adjointe à la faculté de pharmacie de l'Université de Montréal. Elle est chercheuse-boursière FRQ-S Junior I en intelligence artificielle et santé et récipiendaire d'une bourse de recherche en début de carrière CAAIF/IRSC en asthme. Son programme de recherche interdisciplinaire vise à optimiser les issues de l'asthme chez les enfants dans le contexte du système de santé apprenant. Son laboratoire (the ‘TARGET ASTHMA’ lab) combine des méthodes épidémiologiques et biostatistiques de pointe pour identifier des interventions potentielles visant à prévenir l'apparition et la progression de l'asthme pédiatrique ainsi que l’apprentissage automatique pour la découverte de biomarqueurs et l'optimisation des issues de traitement chez les enfants asthmatiques.
Affiliations
- Membre – Centre de recherche Azrieli du CHU Sainte-Justine
Programmes d’enseignement
- DESS en développement du médicament – Sciences de la santé Sciences de la vie
- Maîtrise en sciences pharmaceutiques, option Développement du médicament – Sciences de la santé Sciences de la vie
- Diplôme complémentaire en pharmacothérapie avancée – Sciences de la vie Sciences de la santé
Cours donnés
- PHA6225 Méthodologie de la recherche en pharmacie
- PHM6014 Évaluation critique de l'essai clinique
Expertises
Encadrement Tout déplier Tout replier
Cycle : Maîtrise
Diplôme obtenu : M. Sc.
Projets de recherche Tout déplier Tout replier
BIOlogic drug safety and effectiveness interNational pharmacoepidemiologIC study in pregnant women with autoimmune disorders and asthma and their children (BIONIC) Projet de recherche au Canada / 2024 - 2026
Utilisation de l’apprentissage automatique pour découvrir des endotypes et valider des biomarqueurs non-invasifs afin de prédire les issues de l’asthme chez l’enfant Projet de recherche au Canada / 2022 - 2026
Heterogeneity of interprofessional primary care teams and its effect on quality of care and health service use in older adults Projet de recherche au Canada / 2021 - 2026
Lettre d'octroi - programme de fonds d'opération pour professeure IVADO Projet de recherche au Canada / 2023 - 2025
Treating Asthma by Integrating Learning Algorithms with Omics Research: Moving toward Automated High-Dimensional Endotyping in Children (TAILORMADE) Projet de recherche au Canada / 2022 - 2024
Fonds de démarrage Projet de recherche au Canada / 2021 - 2024
Determinants of fixed airflow obstruction in children with asthma (Rôle: Chercheuse principale Projet de recherche au Canada / 2019 - 2024
ADVerse asthma outcomes from oral ANTibiotic use in children: estimating averAGE causal treatment effects in the presence of residual confounding by indication with Machine Learning (ADVANTAGE-ML) Projet de recherche au Canada / 2022 - 2023
RQRM / ADVerse asthma outcomes from oral ANTibiotic use in children: estimating averAGE causal treatment effects in the presence of residual confounding by indication with Machine Learning (ADVANTAGE-ML) Projet de recherche au Canada / 2022 - 2023
Réseau en santé respiratoire (RSR)/Treating asthma by Integrating Learning algorithms with Omis Research: Moving toward Automated High-dimensional endotyping in Children (TAILOR-MADE) Projet de recherche au Canada / 2022 - 2023
Leveraging big data to optimize treatment and outcomes in children with asthma. Exploiter les mégadonnées pour optimiser le traitement et les résultats chez les enfants asthmatiques Projet de recherche au Canada / 2021 - 2023
Publications Tout déplier Tout replier
Baalbaki N*, Duijvelaar E, Said MM, Schippers J, Bet PM, Twisk J, Fritchley S, Longo C, Mahmoud K, Maitland-van der Zee AH, Bogaard HJ, Swart EL, Aman J, Bartelink IH. Pharmacokinetics and pharmacodynamics of imatinib for optimal drug repurposing from cancer to COVID-19. Eur J Pharm Sci. 2023 May 1;184:106418. doi: 10.1016/j.ejps.2023.106418. Epub 2023 Mar 2. PMID: 36870577; PMCID: PMC9979628.
Marrone E*, Longo C, O'Loughlin J, Villeneuve PJ, Zappitelli M, Bartlett-Esquilant G, Barnett TA. Association between annual exposure to air pollution and systolic blood pressure among adolescents in Montréal, Canada. Health Promot Chronic Dis Prev Can. 2023 Apr;43(4):191-198. doi: 10.24095/hpcdp.43.4.04.
Hosseini B, Tremblay CL, Longo C, Glochi S, White JH, Quach C, Ste-Marie LG, Platt RW, Ducharme FM. Oral vitamin D supplemental therapy to attain a desired serum 25-hydroxyvitamin D concentration in essential healthcare teams. Trials. 2022 Dec 16;23(1):1019. doi: 10.1186/s13063-022-06944-z. PMID: 36527143; PMCID: PMC9756469.
Slob EMA*, Faiz A, van Nijnatten J, Vijverberg SJH, Longo C, Kutlu M, Chew FT, Sio YY, Herrera-Luis E, Espuela-Ortiz A, Perez-Garcia J, Pino-Yanes M, Burchard EG, Potočnik U, Gorenjak M, Palmer C, Maroteau C, Turner S, Verhamme K, Karimi L, Mukhopadhyay S, Timens W, Hiemstra PS, Pijnenburg MW, Neighbors M, Grimbaldeston MA, Tew GW, Brandsma CA, Berce V, Aliee H, Theis F, Sin DD, Li X, van den Berge M, Maitland-van der Zee AH, Koppelman GH. Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response. Clin Transl Allergy. 2022 Aug;12(8):e12173. doi: 10.1002/clt2.12173. PMID: 36036237; PMCID: PMC9421427.
Slob EMA*, Longo C, Vijverberg SJH, Beijsterveldt TCEMV, Bartels M, Hottenga JJ, Pijnenburg MW, Koppelman GH, Maitland-van der Zee AH, Dolan CV, Boomsma DI. Persistence of parental-reported asthma at early ages: A longitudinal twin study. Pediatr Allergy Immunol. 2022 Mar;33(3):e13762. doi: 10.1111/pai.13762. PMID: 35338742.
Longo C, Blais L, Brownell M, Quail JM, Sadatsafavi M, Forget A, Turcot MA, Tavakoli H, Sidhu N, Tan Q, Platt RW, Ducharme FM. Association between asthma control trajectories in preschool and long-term asthma control. JACI in Practice 2022 Jan 17;S2213-2198(22)00008-3. doi: 10.1016/j.jaip.2021.12.033.
Schnitzer M, Guerra S, Longo C, et al. A potential outcomes approach to defining and estimating gestational age-specific exposure effects during pregnancy. Statistical methods in Medical Research, Nov 2021 (in-press).
Cooper S*, Henein M, Mazaniello-Chezol M, Marrone E, Zuyderhoff S, Longo C. Methodological Reflections of a Student- and Community-based Partnership on Operationalizing a Community-based Participatory Research Model: Recommendations for Building, Securing, and Sustaining Partnerships. Prog Community Health Partnersh. 2022;16(3):401-409. doi: 10.1353/cpr.2022.0056. PMID: 36120882
Eger K*, Amelink M, Hashimoto S, Hekking PP, Longo C, Bel EH. Overuse of Oral Corticosteroids, Underuse of Inhaled Corticosteroids, and Implications for Biologic Therapy in Asthma. Respiration. 2022;101(2):116-121. doi: 10.1159/000518514. Epub 2021 Sep 14. PMID: 34535586
Lammers A*, Neerincx AH, Vijverberg SJH, Longo C, Janssen NAH, Boere AJF, Brinkman P, Cassee FR, van der Zee AHM. The Impact of Short-Term Exposure to Air Pollution on the Exhaled Breath of Healthy Adults. Sensors (Basel). 2021 Apr 4;21(7):2518. doi: 10.3390/s21072518. PMCID: PMC8038449.
Issa AM, Carleton B, Gerhard T, Filipski KK, Freedman AN, Kimmel S, Liu G, Longo C, Maitland-van der Zee AH, Sansbury L, Zhou W, Bartlett G. Pharmacoepidemiology: A Time for a New Multidisciplinary Approach to Precision Medicine. Pharmacoepidemiol Drug Saf. 2021 Mar 13. https://doi.org/10.1002/pds.5226. Epub ahead of print. PMID: 33715268.
Slob EMA*, Richards LB*, Vijverberg SJH, Longo C, Koppelman GH, Pijnenburg MWH, Bel EHD, Neerincx AH, Herrera Luis E, Perez-Garcia J, Chew FT, Sio YY, Andiappan AK, Turner SW, Mukhopadhyay S, Palmer CNA, Hawcutt D, Jorgensen AL, Burchard EG, Hernandez-Pacheco N, Pino-Yanes M, Maitland-van der Zee AH. Genome-wide association studies of exacerbations in children using long-acting beta2-agonists. Pediatr Allergy Immunol. 2021 Mar 11. https://doi.org/10.1111/pai.13494. Epub ahead of print. PMID: 33706416.
Principe S*, van Bragt JJMH, Longo C, de Vries R, Sterk PJ, Scichilone N, Vijverberg SJH, Maitland-van der Zee AH. The Influence of Smoking Status on Exhaled Breath Profiles in Asthma and COPD Patients. Molecules. 2021 Mar 4;26(5):1357. doi: 10.3390/molecules26051357. PMID: 33806279; PMCID: PMC7961431.
Issa S*, Longo C, Forget A, Blais L. Association between the timing of asthma diagnosis and medication use during pregnancy. Pharmacotherapy. 2021 Feb 8. https://doi.org/10.1002/phar.2511. Epub ahead of print. PMID: 33555035.
Longo C, Rahimzadeh V, Bartlett G. Communication of Pharmacogenomic test results and treatment plans in pediatric oncology: deliberative stakeholder consultations with parents. BMC Palliat Care. 2021 Jan 12;20(1):15. https://doi.org/10.1186/s12904-021-00709-2. PMID: 33435936; PMCID: PMC7805194.
Orriëns LB*, Vijverberg SJH, Maitland-van der Zee AH, Longo C. Nonadherence to inhaled corticosteroids: A characteristic of the pediatric obese-asthma phenotype? Pediatr Pulmonol. 2021 Jan 12. https://doi.org/10.1002/ppul.25253. Epub ahead of print. PMID: 33434419.
Harris M*, McDonald EG, Marrone E, El-Messidi A, Girard T, Gosselin S, Gunn CM, Shapiro GD, Longo C, Dayan N. Postpartum Analgesia in New Mothers (PAIN) Study: A Survey of Canadian Obstetricians' Post-Delivery Opioid-Prescribing Practices. J Obstet Gynaecol Can. 2020 Dec 13:S1701-2163(20)30974-9. https://doi.org/10.1016/j.jogc.2020.11.018. Epub ahead of print. PMID: 33321248.
Longo C, Blais L, Brownell M, Quail JM, Sadatsafavi M, Forget A, Turcot MA, Nie Y, Li W, Tavakoli H, Tan Q, Fan Y, Platt RW, Ducharme FM. Association between asthma control trajectories in preschoolers and disease remission. Eur Respir J. 2020 Dec 10:2001897. doi: 10.1183/13993003.01897-2020. Epub ahead of print. PMID: 33303530.
Zazuli Z*, Kos R, Veltman JD, Uyterlinde W, Longo C, Baas P, Masereeuw R, Vijverberg SJH, Maitland-van der Zee AH. Comparison of Myelotoxicity and Nephrotoxicity Between Daily Low-Dose Cisplatin With Concurrent Radiation and Cyclic High-Dose Cisplatin in Non-Small Cell Lung Cancer Patients. Front Pharmacol. 2020 Jun 26;11:975. https://doi.org/10.3389/fphar.2020.00975. PMID: 32670072; PMCID: PMC7332698.
Lammers A*, Janssen NAH, Boere AJF, Longo C, Vijverberg SJH, Neerincx AH, Maitland-van der Zee AH, Cassee FR. Effects of short-term exposures to ultrafine particles near an airport in healthy subjects. Environmental International, April 2020 (Accepted).
Richards LB*, van Bragt J, Longo C, Neerincx AH, Bel EHD, Maitland-van der Zee AH. Treatment eligibility of real-life mepolizumab-treated severe asthma patients. JACI In practice, April 2020 (In press).https://doi.org/10.1016/j.jaip.2020.04.029
Slob EMA*, Brew BK, Kats CJR, Vijverberg S, Longo C, Pijnenburg MW, Beijsterveld CM, Koppelman GH, Almqvist C, Boomsma DI, Maitland-van der Zee AH. Early-life antibiotic use and subsequent risk of asthma and eczema: results of a discordant twin study. European Respiratory Journal; 55(4): 1902021, April 2020. https://doi.org/10.1183/13993003.02021-2019
Langlois H*, Cormier M, Villeneuve E, Hoffman RS, Longo C, Gosselin S. Benzodiazepine resistant alcohol withdrawal: What is the clinician's preferred definition? CJEM. 2020 Mar;22(2):165-169. https://doi.org/10.1017/cem.2019.421. PMID: 31645232.
Longo C, Schnitzer M, Forget A, Blais L. Timing of maternal asthma diagnosis in relation to the adverse perinatal outcomes. Journal of Allergy and Clinical Immunology: in Practice [In Press], Feb 2020. DOI: https://doi.org/10.1016/j.jaip.2020.01.04
Gagnon J*, Rahimzadeh V, Longo C, Nugus P, Bartlett G. Understanding How Professional Cultures Impact Implementation of a Pediatric Oncology Genomic Test: The Use of Ethnographic Participant Observation in Deliberative Stakeholder Consultations. Journal of Health Organization and Management; 33 (7/8): 919-928, Nov 2019. DOI: 10.1108/JHOM-10-2018-0297.
Merati N*, Siedlikowski S, Puzhko S, Hamzeh J, Zekri H, Wary N, Longo C. In Their Words: Children’s Perspectives on an El Sistema Music Program’s Effects on their Well-Being. Progress in Community Health Partnerships; 13 (4): 359-369, Dec 2019. DOI: 10.1353/cpr.2019.0069.
Longo C, Bartlett G, Schuster T, Ducharme F, Macgibbon B, Barnett T. The role of weight status in the response to Step-2 maintenance therapies in children with asthma. BMJ Open Respiratory Research, April 2019;6:e000401. doi: 10.1136/bmjresp-2019-00040.
Longo C, Bartlett G, Schuster T, Ducharme F, Macgibbon B, Barnett T. Weight status and nonadherence to maintenance therapy among children with asthma enrolled in a public drug insurance plan. Journal of Asthma, 2019 Mar 26:1-11. doi: 10.1080/02770903.2019.1590593.
Bartlett G, Longo C, Puzhko S, Gagnon J, Rahimzadeh V. Deliberative Stakeholder Consultations: Creating Insights into Effective Practice-Change in Family Medicine. Family Practice, December 2018; DOI: https://doi.org/10.1093/fampra/cmy056.
Longo C, Bartlett G, Schuster T et al. The Obese-Asthma Phenotype in Children: An Exacerbating Situation? Journal of Allergy and Clinical Immunology (JACI), April 2018; DOI: https://doi.org/10.1016/j.jaci.2017.10.052.
Sourial N, Longo C, Videl I, Schuser T. Daring to draw causal claims from non-randomized studies of primary care interventions. Family Practice, April 2018; DOI: https://doi.org/10.1093/fampra/cmy005.
Longo C, Rahimzadeh V, et al. Addressing Ethical Challenges at the Intersection of Pharmacogenomics and Primary Care Using Deliberative Consultations, Pharmacogenomics, Oct 2016. DOI: 10.2217/pgs-2016-0092.
Rahimzadeh V, Bartlett G, Longo C, Ells C. Promoting an ethic of engagement in pediatric palliative care research. BMC Palliative Care; 14(1):50, Oct 2015. DOI: 10.1186/s12904-015-0048-5.
Bartlett G, Rahimzadeh V, Longo C, et al. The future of Genomic Testing in Primary Care: The Changing Face of Personalzied Medicine. Personalized Medicine; 111436(11):477, Oct 2014. DOI: 10.2217/pme.14.36.
Kehayia E, Swaine BR, Longo C, et al. Creating a rehabilitation living lab to optimize social participation and inclusion for persons with physical disabilities. ALTER, European Journal of Disability Research; 8(3): 151-157, July 2014.
Longo C, Bartlett G, MacGibbon B, et al. The Effect of Obesity on Antibiotic Treatment Failure: A Historical Cohort Study. Pharmacoepidemiol Drug Saf; 22: 970-976, June 2013. DOI: 10.1002/pds.3461.
Prix et distinctions
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Fonds de Recherche Québec-Santé (FRQ-S) Chercheur Boursier Junior 1(2023-2027)
CIHR/CAAIF Early Career Researcher Award in Asthma (2022-2024)
EU Horizon 2020 European Respiratory Society Marie-Sklodowska Curie fellowship, RESPIRE-3 (2018-2021)
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