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Rami Al Batran

Vcard

Professeur adjoint

Faculté de pharmacie

Pavillon Jean Coutu local 3216

Courriels

rami.al.batran@umontreal.ca (Travail)

Travail 1 : 514 343-5630

Biographie

Dr Al Batran possède une grande expertise en pharmacologie dans les domaines de l'obésité, de la résistance à l'insuline et du métabolisme énergétique, ainsi que dans les modèles de diabète et maladies cardiovasculaires. Son programme de recherche en cours contribue à la compréhension du métabolisme du corps cétonique dans diverses maladies métaboliques telles que l'obésité et le diabète de type 2.

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Recrutement recherche

About the Lab: The Al Batran lab is looking for an enthusiastic and highly motivated Master and PhD candidate who has a degree in Pharmaceutical Sciences, Molecular Biology, Genetics and/or Biomedical Sciences. The laboratory is located at the Faculty of Pharmacy, University of Montreal, and the Lab offers an attractive and friendly research environment, provides state-of-the-art instrumentation and techniques.

Project Description: This position is available in the laboratory headed by Dr. Rami Al Batran. The project goal is focused on understanding how alterations in energy metabolism at the cellular and molecular levels contribute to obesity-related metabolic disorders including insulin resistance, type 2 diabetes and cardiovascular disease.

How to apply: Applicants should submit their files in one PDF to Dr. Rami Al Batran for further details. The application must include:

  • Cover letter statement of motivation and research interests.
  • CV (summarizing education and list of laboratory experience).
  • Copies of educational certificates (academic transcripts only).
  • A complete list of publications and academic works.
  • List of reference persons: 2-3 references (name, relation to candidate, e-mail and phone number).
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Expertises

Publications Tout déplier Tout replier

Selected Publications:

Eshreif A, Al Batran R, Jamieson KL, Darwesh AM, Gopal K, Greenwell AA, Zlobine I, Aburasayn H, Eaton F, Mulvihill EE, Campbell JE, Seubert JM, Ussher JR. L-citrulline supplementation improves glucose and exercise tolerance in obese mice. Exp Physiol. 2019 Dec 5. doi: 10.1113/EP088109.

Uddin GM, Zhang L, Shah S, Fukushima A, Wagg CS, Gopal K, Al Batran R, Pherwani S, Ho KL, Boisvenue J, Karwi QG, Altamimi T, Wishart DS, Dyck JRB, Ussher JR, Oudit GY, Lopaschuk GD. Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure. Cardiovasc Diabetol. 2019 Jul 5;18(1):86.

Ho KL, Zhang L, Wagg C, Al Batran R, Gopal K, Levasseur J, Leone T, Dyck JRB, Ussher JR, Muoio DM, Kelly DP, and Lopaschuk GD. Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency. Cardiovasc Res. 2019 Feb 18. pii: cvz045.

Al Batran R, Gopal K, Aburasayn H, Eshreif A, Almutairi M, Greenwell AA, Campbell SA, Saleme B, Court EA, Eaton F, Light PE, Sutendra G, Ussher JR. The antianginal ranolazine mitigates obesity-induced hepatic steatosis and increases hepatic dehydrogenase activity. JCI Insight. 2019 Jan 10;4(1). pii: 124643.

Al Batran R, Gopal K, Martin MD, Ho KL, Almutairi M, Aburasayn H, Eaton F, Campbell JE, Ussher JR. Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet. Diabetologia. 2018 Aug;61(8):1849-1855.

Gopal K, Almutairi M, Al Batran R, Eaton F, Gandhi M, Ussher JR. Cardiac-specific deletion of pyruvate dehydrogenase impairs glucose oxidation rates and induces diastolic dysfunction. Front Cardiovasc Med. 2018 Mar 6; 5:17.

Al Batran R, Almutairi M, Ussher JR. Glucagon-like peptide-1 receptor mediated control of cardiac energy metabolism. Peptides. 2018 Feb;100:94-100.

Aburasayn H, Al Batran R, Gopal K, Almutairi M, Eshreif A, Eaton F, Ussher JR. Female offspring born to obese and insulin-resistant dams are not at increased risk for obesity and metabolic dysfunction during early development. Can J Physiol Pharmacol. 2018 Jan;96(1):97-102.

Al Batran R, & Ussher JR. Revisiting protein acetylation and myocardial fatty acid oxidation. Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H617-H619

Gopal K, Saleme B, Al Batran R, Aburasayn H, Eshreif A, Ho KL, Ma WK, Almutairi M, Eaton F, Gandhi M, Park EA, Sutendra G, Ussher JR. FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expression. Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H479-H490.  

Aburasayn H, Al Batran R, Ussher JR. Targeting ceramide metabolism in obesity. Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E423-35.

Prix et distinctions

  • Post-Doctoral Fellowship - Canadian Institutes of Health Research (CIHR/IRSC)

    Post-Doctoral Fellowship - Diabetes Canada

    Post-Doctoral Fellowship - Malaysian Institute of Research Management & Monitoring (IPPP)

    Doctoral Research Scholarship - Malaysian Technical Cooperation Program (MTCP)

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