Publications des 5 dernières années seulement

Laurin KM*, Coutu-Beaudry K*, Salazar A, Méribout N, Audet-Walsh E, Gravel SP. Low expression of PGC-1β and other mitochondrial biogenesis modulators in melanoma is associated with growth arrest and the induction of an immunosuppressive gene expression program dependent on MEK and IRF-1. Cancer Lett. 2022 Aug 10;541:215738. doi: 10.1016/j.canlet.2022.215738.

Mellal K, Omri S, Mulumba M, Tahiri H, Fortin C, Dorion MF, Pham H, Garcia Ramos Y, Zhang J, Pundir S, Joyal JS, Bouchard JF, Sennlaub F, Febbraio M, Hardy P, Gravel SP, Marleau S, Lubell WD, Chemtob S, Ong H. Immunometabolic modulation of retinal inflammation by CD36 ligand, Scientific Reports, 2019, sept 9; 9(1): 12903. doi: 10.1038/s41598-019-49472-8.

Gravel SP. Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and Metastasis. Front Oncol. 2018 Mar 23;8:75. doi: 10.3389/fonc.2018.00075. eCollection 2018. Review

Hulea L*, Gravel SP*, Morita M*, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak MN, Topisirovic I. Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides, Cell Metabolism, 2018, Dec 4;28(6):817-832.e8. doi: 10.1016/j.cmet.2018.09.001. 

Shamalnasab M, Gravel SP, St-Pierre J, Jäger S, Breton L, Aguilaniu H. A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response, Aging Cell, 2018, Dec;17(6):e12830. doi: 10.1111/acel.12830.

Thivierge C, Tseng HW, Mayya V, Lussier C, Gravel SP, Duchaine T. Alternative polyadenylation confers Pten mRNAs stability and resistance to microRNAs, Nucleic Acids Research, 2018, Nov 2;46(19):10340-10352. doi: 10.1093/nar/gky666.

Im YK*, Najyb O, Gravel SP*, McGuirk S, Ahn R, Avizonis D, Chenard V, Sabourin V, Hudson J, Pawson T, Topisirovic I, Pollak MN, St-Pierre J, Ursini-Siegel G. Interplay between ShcA signaling and PGC-1α triggers targetable metabolic vulnerabilities in breast cancer, Cancer Research, 2018, Sep 1;78(17):4826-4838. doi: 10.1158/0008-5472.CAN-17-3696.

Poffenberger MC, Metcalfe-Roach A, Aguilar E, Chen J, Hsu BE, Wong AH, Johnson RM, Flynn B, Samborska B, Ma EH, Gravel SP, Tonelli L, Devorkin L, Kim P, Hall A, Izreig S, Loginicheva E, Beauchemin N, Siegel PM, Artyomov MN, Lum JJ, Zogopoulos G, Blagih J, Jones RG. LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis, Science, 2018, Jul 27;361(6400):406-411. doi: 10.1126/science.aan3975.

Thibault Houles, Simon-Pierre Gravel, Genevieve Lavoie, Sejeong Shin, Mathilde Savall, Antoine Meant, Benoit Grondin, Louis Gaboury, Sang-Oh Yoon, Julie St-Pierre, and Philippe Roux. RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma. Cancer Res. 2018 Feb 12. pii: canres.2215.2017. doi: 10.1158/0008-5472.CAN-17-2215.