My research laboratory is currently in the process of recruiting Master's or PhD students wishing to start their studies on May 1, 2018. If you are interested in the metabolic bases of inflammation and have the skills to undertake one or more original research programs, please send me a letter of intent, a curriculum vitae and the most recent academic transcripts at sp.gravel@umontreal.ca. Candidates presenting the best scientific records and skills will be contacted and met individually during an interview. Candidates must demonstrate good command of the English language.

Education Programs

Life Sciences
Health Sciences
Health Sciences

Courses

PHM6088 Séminaires de sciences pharmaceutiques 1
PHM7090 Séminaires de sciences pharmaceutiques 2

Expertises

Responsabilities and outreach Expand all Collapse all

Participation à des jurys (hors de l’institution)

Student supervision Expand all Collapse all

Stages et autres supervisions

Thèses et mémoires dirigés

Research projects Expand all Collapse all

Deciphering the regulation and role of PGC-1 transcriptional coactivators inhuman skin conditions Projet de recherche au Canada / 2020 - 2024

Lead researcher : Simon-Pierre Gravel

Funding sources: FCI/Fondation canadienne pour l'innovation

Grant programs: PVXXXXXX-Fonds d'exploitation des infrastructures (FEI)

Deciphering the regulation and role of PGC-1 transcriptional coactivators inhuman skin conditions Projet de recherche au Canada / 2018 - 2023

Lead researcher : Simon-Pierre Gravel

Funding sources: FCI/Fondation canadienne pour l'innovation

Grant programs:

Highly versatile benchtop Flow Cytometry Analyzer Projet de recherche au Canada / 2019 - 2022

Lead researcher : Davide Brambilla

Co-researchers : Janelle Drouin-Ouellet , Simon-Pierre Gravel

Funding sources: CRSNG/Conseil de recherches en sciences naturelles et génie du Canada (CRSNG)

Grant programs: PVXXXXXX-(OIR) Outils et d'instruments de recherche (OIR) -1 -(de 7 001 $ à 150 000 $)

Repositionnement du fumarate de diméthyle pour traiter la COVID-19: une molécule à double action au potentiel antiviral et anti-inflammatoire Projet de recherche au Canada / 2020 - 2021

Lead researcher : Simon-Pierre Gravel

Réseau québécois de recherche sur les médicaments (RQRM) - Repositionnement du fumarate de diméthyle pour traiter la COVID-19: une molécule à double action au potentiel antiviral et anti-inflammatoire Projet de recherche au Canada / 2020 - 2021

Co-researchers : Anick Bérard , Simon-Pierre Gravel

Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)

Grant programs: PVXXXXXX-Réseaux thématiques de recherche

Deciphering the regulation and role of PGC-1 transcriptional coactivators inhuman skin conditions Projet de recherche au Canada / 2018 - 2021

Lead researcher : Simon-Pierre Gravel

Funding sources: FCI/Fondation canadienne pour l'innovation

Grant programs: PVXXXXXX-Fonds des leaders

Mise en place d'un laboratoire d'immunopharmacologie métabolique Projet de recherche au Canada / 2017 - 2020

Lead researcher : Simon-Pierre Gravel

Funding sources: Université de Montréal

Grant programs:

Publications Expand all Collapse all

Gravel SP. Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and Metastasis. Front Oncol. 2018 Mar 23;8:75. doi: 10.3389/fonc.2018.00075. eCollection 2018. Review

Thibault Houles, Simon-Pierre Gravel, Genevieve Lavoie, Sejeong Shin, Mathilde Savall, Antoine Meant, Benoit Grondin, Louis Gaboury, Sang-Oh Yoon, Julie St-Pierre, and Philippe Roux. RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma. Cancer Res. 2018 Feb 12. pii: canres.2215.2017. doi: 10.1158/0008-5472.CAN-17-2215.

Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, McLaughlan S, Larsson O, Ohh M, Greenwood C, Choinière L, Bridon G, Avizonis D, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I. Translational and HIF-1alpha-dependent metabolic reprograming underpin oncometabolome plasticity and synergy between oncogenic kinase inhibitors and biguanides (Under review, Cell Metabolism. Published on BioRXIV doi: https://doi.org/10.1101/160879* )

Gravel SP, Avizonis D, St-Pierre J. Metabolomics analyses of cancer cells in controlled microenvironments. Methods Mol Biol. 2016, volume 1458.

Deblois G, Smith H, Tam I, Gravel SP, Caron M, Savage P, Labbe DP, Begin LR, Tremblay ML, Park M, Bourque G, St-Pierre J, Muller WJ, Giguère V. ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer. Nat Commun. 2016 Jul 12;7:12156.

Gandin V, Masvidal L, Hulea L, Gravel SP, Cargnello M, McLaughlan S, Cai Y, Balanathan P, Morita M, Rajakumar A, Furic L, Pollak M, Porco JA Jr, St-Pierre J, Pelletier J, Larsson O, Topisirovic I. nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs. Genome Res. 2016 May;26(5):636-48.

Audet-Walsh É, Papadopoli DJ, Gravel SP, Yee T, Bridon G, Caron M, Bourque G, Giguère V, St-Pierre J. The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer. Cell Rep. 2016 Feb 2;14(4):920-31.

Morita M, Gravel SP, Hulea L, Larsson O, Pollak M, St-Pierre J, Topisirovic I. mTOR coordinates protein synthesis, mitochondrial activity and proliferation. Cell Cycle. 2015;14(4):473-80.

Gravel SP, Hulea L, Toban N, Birman E, Blouin MJ, Zakikhani M, Zhao Y, Topisirovic I, St-Pierre J, Pollak M. Serine deprivation enhances antineoplastic activity of biguanides. Cancer Res. 2014 Dec 15;74(24):7521-33.

Andrzejewski S, Gravel SP, Pollak M, St-Pierre J. Metformin directly acts on mitochondria to alter cellular bioenergetics. Cancer Metab. 2014 Aug 28;2:12.

Gravel SP, Andrzejewski S, Avizonis D, St-Pierre J. Stable isotope tracer analysis in isolated mitochondria from mammalian systems. Metabolites. 2014 Apr 10;4(2):166-83.

Mamer O, Gravel SP, Choinière L, Chénard V, St-Pierre J, Avizonis D. The complete targeted profile of the organic acid intermediates of the citric acid cycle using a single stable isotope dilution analysis, sodium borodeuteride reduction and selected ion monitoring GC/MS. Metabolomics. 2013;9(5):1019-1030

McGuirk S, Gravel SP*, Deblois G, Papadopoli DJ, Faubert B, Wegner A, Hiller K, Avizonis D, Akavia UD, Jones RG, Giguère V, St-Pierre J. PGC-1α supports glutamine metabolism in breast cancer. Cancer Metab. 2013 Dec 5;1(1):22.

Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N. mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab. 2013 Nov 5;18(5):698-711.

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