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Marie Lordkipanidzé

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Professeure agrégée

Faculté de pharmacie

Pavillon Jean Coutu office 2232

marie.lordkipanidze@umontreal.ca

514 343-6111 #15207

Travail 1 : 514 376-3330 #2694

Affiliations

Expertises

Responsabilities and outreach Expand all Collapse all

Titres : corporations et organismes professionnels

Student supervision Expand all Collapse all

Investigation des mécanismes physiologiques menant à la libération du BDNF par les plaquettes et leur susceptibilité aux médicaments antiplaquettaires Thèses et mémoires dirigés / 2021 - 2021
Graduate : Boulahya, Rahma
Cycle : Doctoral
Grade : Ph. D.
Caractérisation des isoformes du brain-derived neurotrophic factor et de ses récepteurs dans les plaquettes humaines Thèses et mémoires dirigés / 2020 - 2020
Graduate : Fleury, Samuel
Cycle : Master's
Grade : M. Sc.
La signalisation du Brain-Derived Neurotrophic Factor et ses récepteurs dans les plaquettes Thèses et mémoires dirigés / 2019 - 2019
Graduate : Boukhatem, Imane
Cycle : Master's
Grade : M. Sc.

Research projects Expand all Collapse all

Chaire de recherche du Canada en Plaquettes comme biomarqueurs et vecteurs Projet de recherche au Canada / 2020 - 2025

Funding sources: SPIIE/Secrétariat des programmes interorganismes à l’intention des établissements
Grant programs: PVX50399-Chaires de recherche du Canada

Neurotrophins in megakaryocytes and platelets Projet de recherche au Canada / 2018 - 2024

Lead researcher : Marie Lordkipanidzé
Co-researchers : Bruce G. Allen
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Neurotrophins in megakaryocytes and platelets Projet de recherche au Canada / 2018 - 2022

Lead researcher : Marie Lordkipanidzé
Co-researchers : Bruce G. Allen
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:

Étude des mécanismes régulant la diversité des rôles plaquettaires dans la santé et la maladie Projet de recherche au Canada / 2016 - 2021

Lead researcher : Marie Lordkipanidzé
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Bourse de chercheur-boursier : Junior 1

Étude des mécanismes régulant la diversité des rôles plaquettaires dans la santé et la maladie Projet de recherche au Canada / 2016 - 2019

Lead researcher : Marie Lordkipanidzé
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Établissement de jeunes chercheurs Juniors 1

Subvention pour la recherche diabète Québec Projet de recherche au Canada / 2016 - 2017

Lead researcher : Marie Lordkipanidzé
Funding sources: Diabète Québec
Grant programs:

DEEP PHENOTYPING OF PATELETS FOR PRECISION MEDICINE IN CARDIOVASCULAR DISEASE Projet de recherche au Canada / 2014 - 2015

Lead researcher : Marie Lordkipanidzé
Funding sources: Regroupement de compagnies, corporations canadiennes
Grant programs:

Publications Expand all Collapse all

2018 - 2020

  1. Fontaine G*, Zagury-Orly I*, de Denus S, Lordkipanidzé M, Beauchesne MF, Maheu-Cadotte MA, White M, Thibodeau-Jarry N, Lavoie P. Effects of reading media on reading comprehension in health professional education: a systematic review protocol. JBI Evid Synth 2020; doi: 10.11124/JBISRIR-D-19-00348
  2. Le Blanc J, Fleury S, Boukhatem I, Bélanger JC, Welman M, Lordkipanidzé M. Platelets selectively regulate the release of BDNF, but not that of its precursor protein, proBDNF. Front Immunol 2020; 11: 575607; doi: 10.3389/fimmu.2020.575607
  3. Al-Hamed FS, Maria OM, Phan J, Al Subaie A, Gao Q, Mansour A, Abu Nada L, Boukhatem I, Elkashty O, Tran SD, Lordkipanidzé M, Badran Z, Tamimi F. Postoperative administration of the acetylcholinesterase inhibitor, donepezil, interferes with bone healing and implant osseointegration in a rat model. Biomolecules 2020; 10: 1318; doi:10.3390/biom10091318
  4. Le Blanc J, Mullier F, Vayne C, Lordkipanidzé M. Advances in platelet function testing - light transmission aggregometry and beyond. J Clin Med 2020; 9: 2636; doi:10.3390/jcm9082636
  5. Harrison P, Lordkipanidzé M, Frelinger AL, Thomas MR, Watson SP. Platelet count and disease - editorial policy. Platelets 2020; 31: 969-970
  6. Ehinger Y, Phamluong K, Darevesky D, Welman M, Moffat JI, Sakhai SA, Whiteley EL, Berger AL, Laguesse S, Farokhnia M, Leggio L, Lordkipanidzé M, Ron D. Differential correlation of serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use. Addict Biol 2020; e12890
  7. Marquis-Gravel G, Mehta SR, Valgimigli M, Levine GN, Neumann FJ, Granger CB, Costa F, Lordkipanidzé M, Roffi M, Robinson SD, Cantor WJ, Tanguay JF. A critical comparison of Canadian and international guidelines recommendations for antiplatelet therapy in coronary artery disease. Can J Cardiol 2020; 36: 1298-1307
  8. Bélanger JC, Bandeira Ferreira FL, Welman M, Boulahya R, Tanguay JF, So DYF, Lordkipanidzé M. Head-to-head comparison of consensus-recommended platelet function tests to assess P2Y12 inhibition; insights for multi-centre trials. J Clin Med 2020; 9: E332
  9. Le Blanc J, Lordkipanidzé M. Platelet function in aging. Front Cardiovasc Med 2019; 6: 109
  10. Chin EM, Gendron E, Li Q, Lordkipanidzé M. Thérapie anti-inflammatoire au canakinumab pour la maladie coronarienne : étude CANTOS. PharmActuel 2019; 51: 18-24
  11. Projean D , Lalonde S, Morin J, Nogues E, Seguin A, Vincent A, Lafrance JP, Masson V, Kassis J, Fafard J, Lordkipanidzé M. Study of the bioaccumulation of prophylactic Tinzaparin in Renally Impaired Patients - The STRIP study. Thromb Res 2019; 174: 48-50 
  12. Discepola V, Schnitzer ME, Jolicoeur EM, Rousseau G, Lordkipanidzé M. Clinical Importance of Thrombocytopenia in Patients with Acute Coronary Syndromes – a Systematic Review and Meta-Analysis. Platelets 2019; 30: 817-27 
  13. Russo JJ, James TE, Ruel M, Dupuis JY, Singh K, Goubran D, Malhotra N, Rubens F, Chong AY, Hibbert B, Boland P, Tran DT, Tanguay JF, Lordkipanidzé M, Perrault L, Wells GA, Bourke M, Chan V, So DY; CArdiovascular Percutaneous Intervention TriAL (CAPITAL) investigators. Ischemic and bleeding outcomes after coronary artery bypass grafting among patients initially treated with a P2Y12 receptor antagonist for acute coronary syndromes - Insights on timing of discontinuation of ticagrelor and clopidogrel prior to surgery. Eur Heart J Acute Cardiovasc Care 2019; 8: 543-53
  14. Ivert T, Dalén M, Ander C, Stålesen R, Lordkipanidzé M, Hjemdahl P. Increased platelet reactivity and platelet-leukocyte aggregation after elective coronary bypass surgery. Platelets 2019; 30: 975-81 
  15. Halford GM, Lordkipanidzé M. An interview with Professor Gus Born. Platelets 2018; 29: 744-8 
  16. Lordkipanidzé M. Platelets at the heart of therapy. Platelets 2018; 29: 103-4
  17. Landry S, Tanguay JF, Lordkipanidzé M. Personalizing antiplatelet therapies; what have we learned from recent trials? Platelets 2018; 29: 131-9  

Communications Expand all Collapse all

2019 - 2020

  1. Fleury S, Boukhatem I, Le Blanc J, Welman M, Lordkipanidzé M. Evidence of the p75 pan-neurotrophic receptor in platelets and comparison to the isoform found in the brain.  Poster presentation at the Thrombosis and Hemostasis Summit of North America (THSNA) 2020. Virtual meeting, Chicago, United States
  2. Jung RG, Simard T, Di Santo P, Duchez AC, Labinaz A, Parlow S, Yang J, Dhaliwal S, Ramirez FD, Xiao F, Lordkipanidzé M, Burger D, Hibbert B. Discovery of plasminogen activator inhibitor-1 platelet -derived extracellular vesicles to predict major adverse cardiac events. American Heart Association: Scientific Sessions Virtual Meeting, 2020. Chicago, United States.
  3. Bélanger JC, Le Blanc J, D’Antono B, Starnino L, Fleury S, Boukhatem I, Welman M, Lordkipanidzé M. Association of platelet activity with circulating levels of Brain-Derived Neurotrophic Factor (BDNF) and cognitive function: a cross-sectional study. Can J Cardiol 2019; 35: S122
  4. Fleury S, Boukhatem I, Bélanger JC, Welman M, Lordkipanidzé M. Large scale assessment of platelet differential secretion. Can J Cardiol 2019; 35: S127-128
  5. Boukhatem I, Lordkipanidzé M. Effect of losartan on platelet responses to classic agonists. Can J Cardiol 2019; 35: S26
  6. Fleury S, Boukhatem I, Le Blanc J, Welman M, Lordkipanidzé M. Interaction entre le BDNF plaquettaire et le récepteur p75NTR. Oral presentation at the Club de Recherche Clinique du Québec 2019, 3-5 October 2019, Estérel, Canada
  7. Le Blanc J, Welman M, Boukhatem I, Fleury S, Lordkipanidzé M. Les plaquettes régulent sélectivement la relâche de BDNF, mais pas de son précurseur, le proBDNF. Oral presentation at the Club de Recherche Clinique du Québec 2019, 3-5 October 2019, Estérel, Canada
  8. Bélanger JC, D’Antono B, Le Blanc J, Welman M, Lordkipanidzé M. Effet du sexe sur les taux plasmatiques de Brain-Derived Neurotrophic Factor. Poster presentation at the Club de Recherche Clinique du Québec 2019, 3-5 October 2019, Estérel, Canada
  9. Boukhatem I, Fleury S, Welman M, Le Blanc J, Allen BG, Lordkipanidzé M. Platelets express a truncated form of TrkB involved in BDNF signaling. Res Pract Thromb Haemost 2019; 3 (suppl 1): 609-610
  10. Lordkipanidzé M, Prévost JC, Pinsonneault M, Pharand C, Diodati JG. Clinical predictiveness of six major platelet function tests used to assess aspirin response in patients with stable coronary artery disease - 10-year follow-up. Res Pract Thromb Haemost 2019; 3 (suppl 1): 620-621
  11. Fleury S, Boukhatem I, Welman M, Le Blanc J, Villeneuve L, Lordkipanidzé M. Expression of the pan-neurotrophic receptor p75NTR in platelets. Arterioscler Thromb Vasc Biol 2019; 39: 283

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