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Marie Lordkipanidzé

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Professeure agrégée

Faculté de pharmacie

Pavillon Jean Coutu office local 2232

Travail 1 : 514 376-3330 #2694

Télécopieur : 514 376-1355

Affiliations

Expertises

Responsabilities and outreach Expand all Collapse all

Titres : corporations et organismes professionnels

Research projects Expand all Collapse all

Neurotrophins in megakaryocytes and platelets Projet de recherche au Canada / 2018 - 2022

Lead researcher : Marie Lordkipanidzé
Co-researchers : Bruce G. Allen
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:

Neurotrophins in megakaryocytes and platelets Projet de recherche au Canada / 2018 - 2022

Lead researcher : Marie Lordkipanidzé
Co-researchers : Bruce G. Allen
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Étude des mécanismes régulant la diversité des rôles plaquettaires dans la santé et la maladie Projet de recherche au Canada / 2016 - 2021

Lead researcher : Marie Lordkipanidzé
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Bourse de chercheur-boursier : Junior 1

Étude des mécanismes régulant la diversité des rôles plaquettaires dans la santé et la maladie Projet de recherche au Canada / 2016 - 2019

Lead researcher : Marie Lordkipanidzé
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Établissement de jeunes chercheurs Juniors 1

Suvention FICM 2015-2018 Projet de recherche au Canada / 2015 - 2019

Lead researcher : Marie Lordkipanidzé
Funding sources: Fondation de l'Institut de cardiologie de Montréal
Grant programs:

Unrestricted grant Aggredyne Projet de recherche au Canada / 2017 - 2018

Lead researcher : Marie Lordkipanidzé
Funding sources: AggreDYNE
Grant programs:

Subvention pour la recherche diabète Québec Projet de recherche au Canada / 2016 - 2017

Lead researcher : Marie Lordkipanidzé
Funding sources: Diabète Québec
Grant programs:

DEEP PHENOTYPING OF PATELETS FOR PRECISION MEDICINE IN CARDIOVASCULAR DISEASE Projet de recherche au Canada / 2014 - 2015

Lead researcher : Marie Lordkipanidzé
Funding sources: Regroupement de compagnies, corporations canadiennes
Grant programs:

Publications Expand all Collapse all

2017 - 2019

  1. Le Blanc J, Lordkipanidzé M. Platelet function in aging. Front Cardiovasc Med 2019; 6: 109
  2. Chin EM, Gendron E, Li Q, Lordkipanidzé M. Thérapie anti-inflammatoire au canakinumab pour la maladie coronarienne : étude CANTOS. PharmActuel 2019; 51: 18-24
  3. Projean D , Lalonde S, Morin J, Nogues E, Seguin A, Vincent A, Lafrance JP, Masson V, Kassis J, Fafard J, Lordkipanidzé M. Study of the bioaccumulation of prophylactic Tinzaparin in Renally Impaired Patients - The STRIP study. Thromb Res 2019; 174: 48-50  
  4. Discepola V, Schnitzer ME, Jolicoeur EM, Rousseau G, Lordkipanidzé M. Clinical Importance of Thrombocytopenia in Patients with Acute Coronary Syndromes – a Systematic Review and Meta-Analysis. Platelets 2019; 30: 817-27 
  5. Russo JJ, James TE, Ruel M, Dupuis JY, Singh K, Goubran D, Malhotra N, Rubens F, Chong AY, Hibbert B, Boland P, Tran DT, Tanguay JF, Lordkipanidzé M, Perrault L, Wells GA, Bourke M, Chan V, So DY; CArdiovascular Percutaneous Intervention TriAL (CAPITAL) investigators. Ischemic and bleeding outcomes after coronary artery bypass grafting among patients initially treated with a P2Y12 receptor antagonist for acute coronary syndromes - Insights on timing of discontinuation of ticagrelor and clopidogrel prior to surgery. Eur Heart J Acute Cardiovasc Care 2019; 8: 543-53
  6. Ivert T, Dalén M, Ander C, Stålesen R, Lordkipanidzé M, Hjemdahl P. Increased platelet reactivity and platelet-leukocyte aggregation after elective coronary bypass surgery. Platelets 2019; 30: 975-81  
  7. Halford GM, Lordkipanidzé M. An interview with Professor Gus Born. Platelets 2018; 29: 744-8  
  8. Lordkipanidzé M. Platelets at the heart of therapy. Platelets 2018; 29: 103-4  
  9. Landry S, Tanguay JF, Lordkipanidzé M. Personalizing antiplatelet therapies; what have we learned from recent trials? Platelets 2018; 29: 131-9  
  10. Messas N, Tanguay JF, Lordkipanidzé M. Tailored antiplatelet therapy in high-risk ACS patients treated with PCI stenting: lessons from the ANTARCTIC trial. J Thorac Dis 2017; 9: E440-3  
  11. Smith C, Thomas SG, Raslan Z, Patel P, Byrne M, Lordkipanidzé M, Bem D, Meyaard L, Senis YA, Watson SP, Mazharian A. Mice lacking the inhibitory collagen receptor LAIR-1 exhibit a mild thrombocytosis and hyperactive platelets. Arterioscler Thromb Vasc Biol 2017; 37: 823-835
  12. Ivert T, Dalén M, Ander C, Stålesen R, Näsman P, Lordkipanidzé M, Hjemdahl P. Platelet function one and three months after coronary bypass surgery in relation to once or twice daily dosing of acetylsalicylic acid. Thromb Res 2017; 149: 64-69  
  13. Siller-Matula JM, Petre A, Delle-Karth G, Huber K, Ay C, Lordkipanidzé M, De Caterina R, Kolh P, Mahla E, Gersh BJ. Impact of preoperative use of P2Y12 receptor inhibitors on clinical outcomes in cardiac and non-cardiac surgery: a systematic review and meta-analysis. Eur Heart J Acute Cardiovasc Care 2017; 6: 753-70

Communications Expand all Collapse all

2017 - 2019

  1. Bélanger JC, Le Blanc J, D’Antono B, Starnino L, Fleury S, Boukhatem I, Welman M, Lordkipanidzé M. Association of platelet activity with circulating levels of Brain-Derived Neurotrophic Factor (BDNF) and cognitive function: a cross-sectional study. Accepted for presentation at the Canadian Cardiovascular Congress 2019, 24-27 October 2019, Montreal, Canada
  2. Fleury S, Boukhatem I, Bélanger JC, Welman M, Lordkipanidzé M. Large scale assessment of platelet differential secretion. Accepted for presentation at the Canadian Cardiovascular Congress 2019, 24-27 October 2019, Montreal, Canada
  3. Boukhatem I, Lordkipanidzé M. Effect of losartan on platelet responses to classic agonists. Accepted for presentation at the Canadian Cardiovascular Congress 2019, 24-27 October 2019, Montreal, Canada
  4. Fleury S, Boukhatem I, Le Blanc J, Welman M, Lordkipanidzé M. Interaction entre le BDNF plaquettaire et le récepteur p75NTR. Oral presentation at the Club de Recherche Clinique du Québec 2019, 3-5 October 2019, Estérel, Canada
  5. Le Blanc J, Welman M, Boukhatem I, Fleury S, Lordkipanidzé M. Les plaquettes régulent sélectivement la relâche de BDNF, mais pas de son précurseur, le proBDNF. Oral presentation at the Club de Recherche Clinique du Québec 2019, 3-5 October 2019, Estérel, Canada
  6. Bélanger JC, D’Antono B, Le Blanc J, Welman M, Lordkipanidzé M. Effet du sexe sur les taux plasmatiques de Brain-Derived Neurotrophic Factor. Poster presentation at the Club de Recherche Clinique du Québec 2019, 3-5 October 2019, Estérel, Canada
  7. Boukhatem I, Fleury S, Welman M, Le Blanc J, Allen BG, Lordkipanidzé M. Platelets express a truncated form of TrkB involved in BDNF signaling. Res Pract Thromb Haemost 2019; 3 (suppl 1): 609-610
  8. Lordkipanidzé M, Prévost JC, Pinsonneault M, Pharand C, Diodati JG. Clinical predictiveness of six major platelet function tests used to assess aspirin response in patients with stable coronary artery disease - 10-year follow-up. Res Pract Thromb Haemost 2019; 3 (suppl 1): 620-621
  9. Fleury S, Boukhatem I, Welman M, Le Blanc J, Villeneuve L, Lordkipanidzé M. Expression of the pan-neurotrophic receptor p75NTR in platelets. Arterioscler Thromb Vasc Biol 2019; 39: 283
  10. Thiboutot Z, Arruda A, Denault JS, Routhier A, Bouziane A, Perreault M, Williamson D, Lordkipanidzé M. Spontaneous intracranial hemorrhage under direct oral anticoagulants versus warfarin. Crit Care Med 2019; 47(1); 354
  11. Boukhatem I, Boulahya R, Fleury S, Welman M, Merhi Y, Allen B. Lordkipanidzé M. Brain-derived neurotrophic factor signalling in platelets. Oral presentation at the 6th International Ottawa Heart Conference. 26 April 2018, Ottawa, Canada
  12. Boulahya R, Béliveau A, Harim A, Ferreira FLB, Tanguay JF, Merhi Y, Lordkipanidzé M. Brain-Derived Neurotrophic Factor Induces Platelet Aggregation. Blood 2017; 130 (suppl 1): 3612
  13. Boulahya R, Lordkipanidzé M. Brain-Derived Neurotrophic Factor in platelets: evidence of release and biological activity. Oral presentation at the Canadian Vascular Network 2017 Annual General Meeting. 23 November 2017, Ottawa, Canada
  14. So DYF, Lordkipanidzé M, McPherson R, Bernick J, Wells GA, Tanguay JF. A Pharmacodynamic Study of a Personalized Strategy for P2Y12 Inhibition Versus Ticagrelor in Reducing Ischemic and Bleeding Risk – The RAPID MANAGE Study. Circulation 2017; 136: A19132
  15. Boulahya R, Boukhatem I, Béliveau A, Merhi Y, Lordkipanidzé M. Détection et identification de la neurotrophine BDNF et son précurseur proBDNF dans les plaquettes humaines. Poster presentation at 17ème Congrès annuel de la Société des sciences vasculaires du Québec. 24-25 November 2017, Québec, Canada
  16. Boulahya R, Ledoux-Hutchinson L, Béliveau A, Vallée-Trudeau JN, Landry S, Merhi Y, Tanguay JF, Lordkipanidzé M. Investigation of the physiological mechanisms leading to the release of BDNF by platelets and their susceptibility to antiplatelet agents. Res Pract Thromb Haemost 2017; 1 (suppl 1): 1334
  17. Projean D, Lalonde S, Morin J, Nogues E, Séguin A, Vincent A, Masson V, Lafrance JP, Fafard J, Kassis J, Lordkipanidzé M. Study of Bioaccumulation of Tinzaparin in Renally Impaired Patients when Given at Prophylactic Dose: The STRIP Study. Res Pract Thromb Haemost 2017; 1 (suppl 1) : 1005
  18. Discepola V, Schnitzer M, Jolicoeur EM, Rousseau G, Lordkipanidzé M. Prevalence and clinical impact of thrombocytopenia in patients with acute coronary syndromes – a systematic review and meta-analysis. J Am Coll Cardiol 2017; 69 (11 suppl) : 134

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