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David Williamson

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Professeur titulaire de clinique

Faculté de pharmacie

Pavillon Jean Coutu office 2181

david.williamson@umontreal.ca

514 343-6111 #1924

Travail 1 : 514 338-2222 #2666

Télécopieur : 514 343-6120

B.Pharm
1996 , Pharmacie , Université de Montréal (Canada)

M.Sc. (pharmacothérapie avancée)
1997 , Pharmacie , Université de Montréal (Canada)

Ph.D
2014 , Sciences cliniques , Université de Sherbrooke (Canada)

Affiliations

  • Membre – CR-HSCM — Centre de recherche de l’Hôpital du Sacré-Cœur de Montréal

Education Programs

  • Health Sciences Life Sciences

Courses

  • PHA6225 Méthodologie de la recherche en pharmacie
  • PHA6320 Ateliers en évaluation de l'information

Expertises

Student supervision Expand all Collapse all

Pharmacological interventions for the hemodynamic management of deceased organ donors Thèses et mémoires dirigés / 2020 - 2020
Graduate : Frenette, Anne Julie
Cycle : Doctoral
Grade : Ph. D.
Les inhibiteurs de pompes à protons comme facteur de risque pour les diarrhées à Clostridium difficile chez des patients de soins intensifs Thèses et mémoires dirigés / 2006 - 2006
Graduate : Beaulieu, Mathieu
Cycle : Master's
Grade : M. Sc.

Research projects Expand all Collapse all

A prospective translational model of the therapeutic potential of cannabidiol in reducing acute pain symptoms and opioid usage following traumatic injury. Projet de recherche au Canada / 2020 - 2026

Lead researcher : Louis De Beaumont
Co-researchers : Gilles Lavigne , Dominique Rouleau , David Williamson , Caroline Arbour , Francis Bernard , Yves De Koninck , James Patrick Near , Louis Gendron , Anne-Marie Pinard
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-Subvention d'équipe

Adverse Drug Events and Medication Errors in adult Intensive Care Units Projet de recherche au Canada / 2021 - 2025

Lead researcher : Nadezhda Roumeliotis
Co-researchers : David Williamson , Christopher Parshuram , Leslie Burry , Kirsten Fiest , Dominique Piquette , Salmaan Kanji
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Prise en charge pharmacothérapeutique des conséquences physiques, comportementales et cognitives des lésions cérébrales traumatiques aiguës Projet de recherche au Canada / 2021 - 2024

Lead researcher : David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Bourse de chercheur-boursier clinicien : Junior 2

Quantity of Opioids for Acute Pain and Limit Unused Medication (OPUM study) Projet de recherche au Canada / 2018 - 2024

Lead researcher : Raoul Daoust
Co-researchers : Gilles Lavigne , Jean Marc Chauny , Dominique Rouleau , Manon Choinière , David Williamson , Marcel Émond , Jacques Simon Lee , Eddy Lang , Sophie Gosselin
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Implantation des meilleures pratiques de gestion de la douleur à l'unité des soins intensifs de traumatology: un travail d'équipe. Projet de recherche au Canada / 2018 - 2021

Lead researcher : Céline Gélinas
Co-researchers : Marc Perreault , Manon Choinière , David Williamson , Francis Bernard
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 3 - Consortium pour le développement de la recherche en traumatologie

Identifier les patients à risque de douleur chronique après un traumatisme craniocérébral modéré/sévère dès les premiers jours d'hospitalisation aux soins intensifs Projet de recherche au Canada / 2018 - 2021

Lead researcher : Caroline Arbour
Co-researchers : Louis De Beaumont , David Williamson , Francis Bernard
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 1 - Consortium pour le développement de la recherche en traumatologie

Sedatives newly prescribed following intensive care unit admission among sedative-naïve elderly patients: Understanding the risk of falls and determining targets for deprescribing (SNOW-FALL) Projet de recherche au Canada / 2018 - 2020

Lead researcher : Lisa Denise Burry
Co-researchers : David Williamson
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Agitation et délirium en traumatologie et aux soins intensifs Projet de recherche au Canada / 2016 - 2020

Lead researcher : David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Bourse de chercheur-boursier clinicien : Junior 1

PROSPECT: Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial Projet de recherche au Canada / 2016 - 2020

Lead researcher : Jennie Johnstone
Co-researchers : David Williamson , Emmanuel Charbonney
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:

Revue systématique et méta-analyse sur les agents sédatifs en traumatisme crânien Projet de recherche au Canada / 2017 - 2019

Lead researcher : David Williamson
Funding sources: Fondation NeuroTrauma Marie-Robert
Grant programs:

Agitation et délirium en traumatologie et aux soins intensifs Projet de recherche au Canada / 2016 - 2019

Lead researcher : David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Établissement de jeunes chercheurs Juniors 1

Traitement des hémorragies intracrâniennes chez les patients anticoagulés ayant subi un traumatisme crânien léger : Revue systématique et méta-analyse Projet de recherche au Canada / 2016 - 2018

Lead researcher : Jean Marc Chauny
Co-researchers : Martin Albert , David Williamson , Natalie Le Sage
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 4 - Consortium pour le développement de la recherche en traumatologie

Managing Pain In Collaboration in the Intensive Care Unit (MPIC-ICU): A Stepped Wedge Cluster Randomized Trial. Projet de recherche au Canada / 2016 - 2017

Lead researcher : Céline Gélinas
Co-researchers : Manon Choinière , David Williamson , Emmanuel Charbonney , Francis Bernard
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Interventions pharmacologiques pour le contrôle du délirium et de l'agitation suite à un traumatisme cranio-cérébral: une revue systématique de données cliniques et précliniques Projet de recherche au Canada / 2015 - 2017

Lead researcher : David Williamson
Co-researchers : Marc Perreault , Jean-François Giguère , Anne Julie Frenette , Emmanuel Charbonney , Francis Bernard , François Lamontagne , Leslie Burry , Marie-Julie Potvin
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 4 - Consortium pour le développement de la recherche en traumatologie

Publications Expand all Collapse all

  1. Johnstone J, Meade M, Lauzier F, Marshall J, Duan E, Dionne J, Arabi Y, Heels-Ansdell D; Thabane L, Lamarche D; Surette M; Zytaruk N, Mehta S, Dodek, P, Mcintyre L, English S; Rochwerg B,Karachi T, Henderson W, Wood G, Ovakim D, Herridge M, Granton J, Wilcox E, Gioffi A, Stelfox H; Niven D, Muscedere, J, Lamontagne F, D'Aragon, F, St-Arnaud C, Ball I, Nagpal D, Girard M, Aslanian P, Charbonney E, Williamson D, Sligl W, Friedrich J, Adhikari N; Marquis F, Archambault P, Khwaja K, Kristof A, Kutsiogiannis J, Zarychanski R, Paunovic, B, Reeve B, Lellouche F, Hosek P, Tsang J, Binnie A, Trop S, Loubani O, Hall R, Cirone R, Reynolds S, Lysecki P, Golan E, Carten Ceba R, Taylor R, Cook D. Lactobacillus Rhamnosus GG in Critical Illness: A Randomized Trial. JAMA 2021;326:1024-33.
  2. Burry LD, Cheng W, Williamson DR, Adhikari NK, Egerod I, Kanji S, Martin CM, Hutton B, Rose L. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Med 2021;47:943-60.

  3. Saavedra-Mitjans M, David PM, Frenette AJ, Arbour C, Perreault M, Williams V, Bernard F, Williamson D. EXperienceS and aTtitudes towards Agitated behaviours in Traumatic brain injury in the Intensive Care unit patients (EXSTATIC): a protocol for an interprofessional mixed-method study. BMJ Open. 2021;11:e045816. 

  4. Duceppe MA, Kanji S, Ruo N, Do A, Cavayas YA, Robert-Halabi M, Albert M, Zavalkoff S, Samoukovic G, Williamson DR. Alterations in the pharmacokinetics and pharmacodynamics of commonly used antimicrobials in critical care patients during extracorporeal membrane oxygenation: A systematic review. Drugs 2021;81:1307-1329.

  5. Morris JL, Bernard F, Bérubé M, Dubé JN, Houle J, Laporta D, Morin SN, Perreault M, Williamson D, Gélinas C. Determinants of Pain Assessment Documentation in Intensive Care Units. Can J Anesth 2021; 68(8):1176-1184.

  6. Duong A, Simard C, Wang YL, Williamson D, Marsot A. Aminoglycosides in the intensive care unit: what’s new in population PL modeling. Antibiotics 2021;10:507.
  7. Williamson DR, Kanji S, Burry LD. The Clinician scientist. Can J Hosp Pharm 2021;74:130-4.
  8. Bilodeau V, Saavedra Mitjans M, Frenette AJ, Burry L, Albert M, Bernard F, Williamson DR. Safety of dexmedetomidine for the control of agitation in critically ill traumatic brain injury patients: a descriptive study. J Clin Pharm Ther 2021; 46:1020-1026.
  9. Bendayan M, Mardigyan V, Williamson D, Chen-Tournoux A, Eintracht S, Rudski L, MacNamara E, Blostein M, Afilalo M, Afilalo J. Association of Muscle Mass With Direct Oral Anticoagulant Activity in Older Adults. J Am Geriatr Soc 2021;69:1012-1018.
  10. Williamson DR, Cherifa SI, Frenette AJ, Saavedra Mitjans M, Charbonney E, Cataford G, Williams V, Lainer Palacios J, Burry L, Mehta S, Arbour C, Bernard F; Canadian Critical Care Trials Group. Agitation, confusion, and aggression in critically ill traumatic brain injury-a pilot cohort study (ACACIA-PILOT). Pilot Feasibility Stud. 2020;6:193.
  11. Gagnon A, Laroche M, Williamson DR, Giguère JF, Giroux M, Bernard F. Incidence and characteristics of cerebral hypoxia after craniectomy in brain injured patients: a cohort study. J Neurosurgery (ePub 5 nov 2020)
  12. Flynn F, Richard G, Dobrescu MA, Bouchard J, Williamson DR, Brindamour D, Charbonney E, Dupuis S. Refractory dabigatran-induced hemorrhage despite multiple idarucizumab administration and renal replacement therapy. J Pharm Pract (ePub 28 septembre)
  13. Frenette AJ, Williamson DR, Rochwerg B, Weiss MJ, Ball I, D’Aragon F, Serri K, Brindamour D, Meade M, Charbonney E.Worldwide management of donors after neurological death: a systematic review and narrative synthesis of guidelines. Can J Anesth 2020;67:1839-57.
  14. Cavayas YA, Noël A, Brunette V, Williamson DR, Bellemare P, Lagrenade-Verdant C, LeGuillan S, Levesque E, Frenette AJ, Lamarche Y, Giasson M, Rico P, Beaulieu Y, Marsolais P, Serri K, Bernard F, Albert M. Early experience with critically ill patients with COVID-19 in Montreal. Can J Anesth 2021;68:204-213.
  15. Burry LD, Barletta J, Williamson D, , Kanji S, Maves RC, Dichter J, Christian MD, Geiling J, Erstad B. It Takes a Village… Contending with Drug Shortages During Disasters. Chest 2020;158:2414-2424.
  16. Jutras M, Williamson DR, Chassé M, Leclair G. Development and validation of a liquid chromatography coupled to tandem mass spectrometry method for the simultaneous quantification of five analgesics and sedatives, and six of their active metabolites in human plasma: Application to a clinical study on the determination of neurological death in the intensive care unit. J Pharm Biomed Anal 2020;190:113521.
  17. Sneyers B, Duceppe MA, Frenette AJ, Burry LD, Rico P, Lavoie A, Gélinas C, Mehta S, Dagenais M, Williamson DR, Perreault MM. Strategies for the Prevention and Treatment of Iatrogenic Withdrawal from Opioids and Benzodiazepines in Critically Ill Neonates, Children and Adults: A Systematic Review of Clinical Studies. Drugs 2020;26:1-23.
  18. Kanji S, Burry L, Williamson D, Pittman M, Dubinsky S, Patel D, Natarajan S, MacLean R, Huh JH, Scales D, Neillipovitz D. Therapeutic Alternatives and Strategies for Drug Conservation in the ICU During Times of Drug Shortage. Can J Anesth 2020;67:1405-1416
  19. Burry L, Hutton B, Williamson DR, Mehta S, Adhikari NKJ, Cheng W, Ely EW, Egerod I, Fergusson DA, Rose L. Pharmacological interventions for the treatment of delirium in critically ill adults. Cochrane Database of Systematic Reviews 2019, Issue 8. Art. No.: CD011749. DOI: 10.1002/14651858.CD011749.pub2.
  20. Capilnean A, Martone A, Sandu PR, Rosu VA, Murgoi P, Frenette AJ, Williamson DR, Lecavalier A, Javaraman D, Rico P, Bellemare P, Gelinas C, Perreault MM. Withdrawal assessment in the adult ICU population. Am J Crit Care 2019; 28:361-369.
  21. Frenette AJ, Veillette C, Poulin F, Albert M, Marsolais P, Bernard F, D’Aragon F, Williamson D, Charbonney E, Serri K. Evaluation of left and right heart function by echocardiography in potential heart donors: a cohort study. J Crit Care 2019; 15;54:37-41
  22. Williamson DR, Frenette AJ, Perreault MM, Burry LD, Charbonney E, Lamontagne F, Potvin MJ, Giguère JF, Mehta S, Bernard F. Pharmacological interventions for agitated behaviors in traumatic brain injury: a systematic review. BMJ Open 2019; 9:e029604.
  23. Fortier M, Ferreira V, Pinsonneault M, Pistre P, Meideros Charbonneau J, Buisson A, Proulx C, Guenette S, Bally M, Williamson DR, Ang A. Impact of a pharmacist antimicrobial checklist on hospital antimicrobial use: A patient-level interrupted time series study. J Hosp infection 2019; 103:251-258.
  24. Sokoloff C, Williamson D, Serri K, Albert M, Odier C, Charbonney E and Bernard F. Trans-cranial Doppler as an Inference Tool of Cerebral Hypoxic Episodes Early after Moderate and Severe TBI. Neurocritical Care  (ePub 19 juin)
  25. Frenette AJ, Williamson DR, Williams V, Lagacé AM, Charbonney E Serri K. Efficacy and safety of levothyroxine on cardiac function in brain dead organ donors: a pilot study. Prog Transplant 29:261-268.
  26. Daoust R, Paquet J, Cournoyer A, Piette E, Morris J, Lessard J, Castonguay V, Williamson D, Chauny JM. Opioid Induced Side Effects, Including Constipation, For The Acute Pain of Emergency Department Discharged Patients. Am J Emerg Med (ePub 5 juin)
  27. Frenette AJ, Charbonney E, D’Aragon F, Serri K, Marsolais P, Chassé M, Meade M, Williamson DR. A Canadian Survey of Deceased organ donor’s management centered on hemodynamic and hormonal aspects. Can J Anesth 2019; 66:1162-1172.
  28. Dupuis S, Brind’amour D, Karzon S, Bellemare P, Charbonney E, Frenette AJ, Burry L, Perreault MM, Williamson DR. Pharmacological interventions used to facilitate mechanical ventilation weaning in difficult to wean patients: a systematic review and meta-analysis. Can J Anesth 2019;66(3) :318-327
  29. Duceppe MA, Perreault MM, Frenette AJ, Burry LD, Rico P, Lavoie A, Gélinas C, Mehta S, Dagenais M, Williamson DR. Frequency, risk factors and symptomatology of iatrogenic withdrawal from opioids and benzodiazepines in critically Ill neonates, children and adults: A systematic review of clinical studies. J Clin Pharm Ther 2019; 44:148-156.
  30. Dellazizzio L, Demers SP, Charbonney E, Williams V, Serri K, Albert M, Williamson DR, Bernard F. Minimal PaO2 threshold after Traumatic Brain Injury and clinical utility of a novel Brain Oxygenation Ratio (BOx Ratio). J Neurosurg (Published online November 2, 2018; DOI: 10.3171/2018.5.JNS18651)
  31. Wang HT, Williamson DR, Francispillai M, Richard-Denis A, Albert M. Pneumonia as a modifiable risk factor of mechanical ventilation and prolonged mechanical ventilation in cervical spinal chord injuries. Can Journal of Respiratory, Critical Care, and Sleep Medicine 2018;2:213-217
  32. Chartrand M, Martineau J, Brouillette D, Williamson DR, Côté S, Landry J, Huot R, White-Guay B, Hudon E, Perreault S, Kano G, Martin E, Gagnon MM, Lalonde L. Quality indicators for community pharmacist management of anticoagulation. J Manag Care Pharm 2018; 24:357-365
  33. Wang PP, Huang E, Feng X, Bray CA, Perreault MM, Rico P, Bellemare P, Murgoi P, Gélinas C, Lecavalier A, Jayaraman D, Frenette AJ, Williamson DR. Iatrogenic Withdrawal Syndrome due to Opioids in Critically Ill Patients: a Multicenter Prospective Cohort Study. Ann Intensive Care 2017;7:88.
  34. Ada Chiu, Lisa Burry, Jennifer Korman, Marc Perreault, David Williamson, Sangeeta Mehta. Opioid Withdrawal in Critically Ill Patients: Frequency, Risk Factors, and A Review of Current Assessment Tools. Ann Pharmacother 2017; 51:1099-1111.
  35. Burry L, Williamson D, Perreault MM, Smith O, Mantas I, Fergusson DA, Mehta S, Rose L. Delirium and exposure to psychoactive medications in critically ill adults: A multi-centre observational study. J Crit Care. 2017;42:268-274
  36. Arnold DM, Lauzier F, Albert M, Williamson D, Li N, Zarychanski R, Doig C, McIntyre L, Freitag A, Crowther M, Saunders L, Clarke F, Cooper J, Qushmaq I, Lopes RD, Heels-Ansdell D, Webert K, Cook D. The Association Between Platelet Transfusions and Bleeding in Critically Ill Patients with Thrombocytopenia. Res Pract Thromb Haemost. 2017;103–111.
  37. Doré M, San Juan A, Frenette AJ, Williamson DR. Clinical importance of monitoring the unbound valproic acid concentration in patients with hypoalbuminemia. Pharmacotherapy 2017; 37(8):900-907.
  38. Burry LD, Scales D,Williamson DR, Mehta S, Wilcox E, Bernard F, Azad A, Fan E, Rose L. for Prevention of in Critically Ill Patients (MELLOW-1) – Study protocol. BMJ Open 2017 Mar 30;7(3):e015420.
  39. Duceppe MA*,Williamson D*, Elliott A, Para M, Poirier MC, Delisle MS, Frenette AJ, Deckelbaum D, Razek T, Desjardins M, Bertrand JC,Bernard F, Rico P, Burry L, Perreault MM. Modifiable risk factors for delirium in critically ill trauma patients: a multicenter prospective study. J Intensive Care Med E-Pub (24 mars 2017)
  40. Chapdelaine A, Doré M, Troyanov Y, Williamson DR, Mansour AM. Metabolite monitoring to guide thiopurine therapy in systemic autoimmune diseases. Clin Rheumatol 2017;36 :1341-8.
  41. Albert M, Corsilli D, Williamson DR, Brosseau M, Bellemare P, Delisle S, Nguyen AQN, Varin F. Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome. World J Crit Care Med 2017; 2017 Feb 4;6:74-78.
  42. Williamson DR, Frenette AJ, Perreault MM, Burry LD, Charbonney E, Lamontagne F, Potvin MJ, Giguère JF, Mehta S, Bernard F. Pharmacological interventions for agitation and delirium in traumatic brain injury: a systematic review and meta-analysis. Protocol. Syst Rev 2016 Nov 17;5:193.
  43. Hutton B, Burry LD, Kanji S, Mehta S, Guenette M; Martin CM, Fergusson DA, Adhikari NK, Egerod I, Williamson D, Straus D, Moher D, Ely EW, Rose L. Comparison of sedation strategies for critically ill patients: A protocol for a systematic review incorporating network meta-analyses. Syst Reviews 2016;20:157.
  44. Burry L, Hutton B, Guenette M, Williamson D, Mehta D; Egerod I; Kanji S, Adhikari NK, Moher D, Martin C, Rose L. Comparison of pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: A protocol for a systematic review incorporating network meta-analyses. Syst Reviews  2016;5:153.
  45. Chauny JM, Marquis M, Laroche M, Bernard F, Williamson D, Albert M, Daoust R. Risk of Delayed Traumatic Intracranial Hemorrhage in Anticoagulated Patients with Minor Blunt Head Trauma: Systematic Review and Meta-analysis. Ann Emerg Med 2016;51:519-528.
  46. Dupuis S, Vinet J, Arfa T, Williamson DR, Perreault MM. Survey on decisional factors influencing pharmacy students’ decisions to pursue hospital residency training. Can J Hosp Pharm 2016 ;69:209-15.
  47. Thiboutot Z, Perreault MM, Williamson DR, Mehta S, Rose L, Burry LD. Delirium screening and use of antipsychotics in mechanically ventilated patients in Canadian intensive care units. Can J Hosp Pharm 2016 ; 69:107-13
  48. Serri K, El Rayes M, Giraldeau G, Williamson DR, Bernard F. Traumatic brain injury is not associated with significant myocardial dysfunction. Scand J Trauma Resus Emerg Med 2016;24:31.
  49. Frenette AJ, Bebawi, E, Deslauriers L, Tessier AA, Perreault MM, Delisle MS, Bertrand JC, Rico P, Bernard F, Desjardins M, Kwaja K, Burry L, Williamson DR. Validating and comparing the CAM-ICU and the ICDSC in mild and moderate traumatic brain injury patients: A multicenter prospective study. Intensive Care Med 2016;42(1):122-3.
  50. Bernier-Jean A, Albert M, Shiloh AL, Eisen LA, Williamson D, Beaulieu Y.The Diagnostic and therapeutic impact of Point-of-Care ultrasonography in the intensive care unit. J Intensive Care Med 2017;32:197-203.

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