Daniel Lévesque
- Professeur titulaire
-
Faculté de pharmacie
Pavillon Jean Coutu office local 3216
Télécopieur : 514 343-7073
Web : CV
Doctorat
1991
, Pharmacie , Université Laval (Canada)
Stage postdoctoral
1995
, Neurosciences , INSERM U109 (France)
Affiliations
- Membre – GRSNC — Groupe de recherche sur le système nerveux central
- Membre – GRUM — Groupe de recherche universitaire sur le médicament
- Membre – CIRCA — Centre interdisciplinaire de recherche sur le cerveau et l'apprentissage
Expertises
Student supervision Expand all Collapse all
Research projects Expand all Collapse all
Soutien Médicament Québec Projet de recherche au Canada / 2021 - 2023
Identification of lead compounds for modulation of Nur77 /RXR receptor complex activity in the management of L-Dopa-induced dyskinesia in Parkinson's disease Projet de recherche au Canada / 2020 - 2023
THE ROLE OF TRANSCRIPTION FACTORS NUR77 AND RETINOID X RECEPTOR (RXR) IN THE EFFECT OF ANTIPSYCHOTIC DRUG Projet de recherche au Canada / 2013 - 2021
SUBVENTION D'INFRASTRUCTURE DU FRSQ POUR LE GRSNC(GROUPE DE RECHERCHE SUR LE SYSTÈME NERVEUX CENTRAL) Projet de recherche au Canada / 2002 - 2020
Neural mechanisms that sub-serve sensitization to the behavioral effects of psychostimulant drugs. Projet de recherche au Canada / 2017 - 2019
NUR77 and RXR : New Targets in Drug-Induced Dyskinesia. Projet de recherche au Canada / 2017 - 2018
NUR77 and RXR : New Targets in Drug-Induced Dyskinesia. Projet de recherche au Canada / 2017 - 2017
Identification of Nurrl / RXR complex agonists for neuroprotection Projet de recherche au Canada / 2016 - 2017
NEUROTENSIN MODULATION OF LIMBIC NEUROTRANSMISSION Projet de recherche au Canada / 2010 - 2016
RESEAU DE RECHERCHE EN SANTE BUCCODENTAIRE ET OSSEUSE (RSBO) GROUPE DE RECHERCHE INTERDISCIPLINAIRE SUR LA DYSKINESIE (GRID): NOUVELLES APPROCHES MOLECULAIRES ET PHARMACOLOGIQUES VERS LA PREVENTION ET LE TRAITEMENT D Projet de recherche au Canada / 2012 - 2015
NUCLEAR RECEPTORS AND DOPAMINE NEUROTRANSMISSION: A YIN-YANG RELATIONSHIP Projet de recherche au Canada / 2012 - 2014
NUCLEAR RECEPTORS AND DOPAMINE NEUROTRANSMISSION: A YIN-YANG RELATIONSHIP Projet de recherche au Canada / 2008 - 2014
IN SITU-FORMING IMPLANTS OF RIVASTIGMINE IN THE TREATMENT OF ALZHEIMER'S DISEASE Projet de recherche au Canada / 2008 - 2014
IN SITU-FORMING IMPLANTS OF RIVASTIGMINE IN THE TREATMENT OF ALZHEIMER'S DISEASE Projet de recherche au Canada / 2009 - 2011
ANALYSES MOLECULAIRES ET CELLULAIRES DE L'EFFET DES AGENTS ANTIPSYCHOTIQUES SUR LE FACTEUR DE TRANSCRIPTION NUR77 Projet de recherche au Canada / 2008 - 2011
Publications Expand all Collapse all
Publications récentes:
Schweizer N, T Viereckel, C Smith-Anttila, K Nordenankar, E Arvisson, S Mahmoudi, A Zampera, H Warner Jonsson, J Bergquist, D Lévesque, A Konradsson-Geuken, M Andersson, S Dumas and A Wallen-Mackenzie, Reduced sugar consumption and altered size of subtalamic nucleus identify a role for Pitx2/Vglut2 co-expressing neurons in action selection, eNeuro, 3(5) e0264-16, 2016.
Fakhoury M, D Voyer, D Lévesque and PP Rompré, Effect of electrolytic lesions of the dorsal diencephalic conduction system on the distribution of Fos-like immunoreactivity induced by rewarding electrical stimulation, Neuroscience, 334: 214-225, 2016.
Voyer D, Lévesque D and PP Rompré, Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: a role for NMDA receptors, Neuropharmacology, 112: 150-163, 2016.
Giner X, D Cotnoir-White, S Mader and D. Lévesque, Selective ligand activity at Nur/retinoid X receptor complexes revealed by dimer-specific bioluminescence resonance energy transfer-based sensors, FASEB J, 29: 4256-4267 2015.
Hernandez G, A Khodami-Pour, D Lévesque and PP Rompré, Reduction in ventral midbrain NMDA receptors reveals two opposite modulatory roles for glutamate on reward, Neuropsychopharmacology, 40: 1682-1691, 2015.
Rocchetti J, Isingrini E, Dal Bo G, Sagheby S, Menagaux A, Tronche F, Lévesque D, Moquin L, Gratton A, Wong TP, Rubinstein M and Giros B, Presynaptic D2 dopamine receptors control LTD expression and memory processes in the temporal hippocampus, Biol. Psychiatry, 77: 513-525, 2015.
Mahmoudi S, Lévesque D and Blanchet PJ, Upregulation of dopamine D3, but not D2, receptors correlates with tardive dyskinesia in primate model, Mov. Disorders, 29: 1125-1133, 2014. This paper was highlighted in the journal’s editorial section, Jenner P, A late appearance by the dopamine D-3 receptor, Mov. Disorders, 29: 1094-1096, 2014.
Schweizer N, Pupe S, Arvidsson E, Nordenankar K, Smith-Anttila CJA, Mahmoudi S, Andren A, Dumas S, Rajagopalan A, Lévesque D, Leao RN and Wallen-Mackenzie A, Limiting glutamatergic transmission in a Vglut2-expressing subpopulation of the subtalamic nucleus is sufficient to cause hyperlocomotion, Proc. Natl. Acad. Sci. USA, 111: 7837-7842, 2014.
Bouayad-Gervais K, Minogianis EA, Lévesque D and Samaha AN, The self administration of rapidly delivered cocaine promotes increased motivation to take the drug: contributions of prior levels of operant responding and cocaine intake, Psychopharmacology (Berlin), 231: 4241-4252, 2014.
Mahmoudi S, PJ Blanchet and D Lévesque, Haloperidol-induced Nur77 expression in non-human primate model is associated with tardive dyskinesia, Eur. J. Neurosci., 38: 2192-2198, 2013.
Minogianis EA, D Lévesque and AN Samaha, The speed of cocaine delivery determines the subsequent motivation to self-administer the drug, Neuropsychopharmacology, 38: 2644-2656, 2013.
Bédard AM, J Maheux, D Lévesque and AN Samaha, Prior haloperidol, but not olanzapine, exposure augments the pursuit of reward cues: implications for substance abuse in schizophrenia, Schizophrenia Bull., 39: 692-702, 2013.
Samadi P, Boutet A, Rymar V, Rewal K, Maheux J, Chakrya-Kvann J, Tomaszewski M, Beaubien F, Cloutier JF, Lévesque D and Sadikot A, Relationship between BDNF expression in major striatal afferents, striatum morphology and motor behavior in the R6/2 mouse model of Huntington’s disease, Genes, Brain and Behav., 12: 108-124, 2013.
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