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David Williamson

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Professeur titulaire de clinique

Faculté de pharmacie

Pavillon Jean Coutu office 2181

david.williamson@umontreal.ca

514 343-6111 #1924

Travail 1 : 514 338-2222 #2666

Télécopieur : 514 343-6120

B.Pharm
1996 , Pharmacie , Université de Montréal (Canada)

M.Sc. (pharmacothérapie avancée)
1997 , Pharmacie , Université de Montréal (Canada)

Ph.D
2014 , Sciences cliniques , Université de Sherbrooke (Canada)

Affiliations

  • Membre – CIUSSS NIM — Centre de recherche du CIUSSS Nord-de-l’île-de-Montréal

Education Programs

  • Health Sciences
  • Health Sciences

Courses

  • PHM6514 Soins pharm. urgence et soins critiques

Expertises

Student supervision Expand all Collapse all

Influence potentielle des médicaments sédatifs et analgésiques sur le diagnostic de décès neurologique Thèses et mémoires dirigés / 2023 - 2023
Graduate : Kolan, Christophe
Cycle : Master's
Grade : M. Sc.
Pharmacological interventions for the hemodynamic management of deceased organ donors Thèses et mémoires dirigés / 2020 - 2020
Graduate : Frenette, Anne Julie
Cycle : Doctoral
Grade : Ph. D.
Les inhibiteurs de pompes à protons comme facteur de risque pour les diarrhées à Clostridium difficile chez des patients de soins intensifs Thèses et mémoires dirigés / 2006 - 2006
Graduate : Beaulieu, Mathieu
Cycle : Master's
Grade : M. Sc.

Research projects Expand all Collapse all

Impact of Vitamin C on the Reduction of Opioid Consumption After an Emergency Department Visit for Acute Musculoskeletal Pain: A Double-Blind Randomized Control Trial Projet de recherche au Canada / 2023 - 2028

Lead researcher : Raoul Daoust
Co-researchers : Dominique Rouleau , David Williamson , Caroline Arbour , Alexis Cournoyer , Perry Jeffery , Marcel Émond
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Effects of dexmedetomidine on agitation in critically ill TBI patients – DEX-TBI Projet de recherche au Canada / 2024 - 2027

Lead researcher : David Williamson
Co-researchers : Francis Bernard , Marc Perreault , Caroline Arbour , Catherine Duclos , Marie-Julie Potvin , Kosar Ali Khwaja , Robert Allston Fowler , Lisa Burry , Donald Griesdale
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Large reductions in arterial CARbon dioxide and development of acute Brain Injury in invasively mechanically ventilated patients with acute respiratory failure (CARBI) Projet de recherche au Canada / 2022 - 2026

Lead researcher : Yiorgos Alexandros Cavayas
Co-researchers : Francis Bernard , Laurent Létourneau-Guillon , François Carrier , Mireille Schnitzer , David Williamson , Eddy Fan , Lorenzo Del Sorbo , Laveena Munshi
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

A prospective translational model of the therapeutic potential of cannabidiol in reducing acute pain symptoms and opioid usage following traumatic injury. Projet de recherche au Canada / 2020 - 2026

Lead researcher : Louis De Beaumont
Co-researchers : Gilles Lavigne , Francis Bernard , Dominique Rouleau , David Williamson , Caroline Arbour , Louis Gendron , Yves De Koninck , James Patrick Near , Anne-Marie Pinard
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-Subvention d'équipe

Adverse Drug Events and Medication Errors in adult Intensive Care Units Projet de recherche au Canada / 2021 - 2025

Lead researcher : Nadezhda Roumeliotis
Co-researchers : David Williamson , Leslie Burry , Christopher Parshuram , Kirsten Fiest , Dominique Piquette , Salmaan Kanji
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Prise en charge pharmacothérapeutique des conséquences physiques, comportementales et cognitives des lésions cérébrales traumatiques aiguës Projet de recherche au Canada / 2021 - 2024

Lead researcher : David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Bourse de chercheur-boursier clinicien : Junior 2

Quantity of Opioids for Acute Pain and Limit Unused Medication (OPUM study) Projet de recherche au Canada / 2018 - 2024

Lead researcher : Raoul Daoust
Co-researchers : Gilles Lavigne , Manon Choinière , Jean Marc Chauny , Dominique Rouleau , David Williamson , Jacques Simon Lee , Marcel Émond , Eddy Lang , Sophie Gosselin
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Identifier les patients à risque de douleur chronique après un traumatisme craniocérébral modéré/sévère dès les premiers jours d'hospitalisation aux soins intensifs Projet de recherche au Canada / 2018 - 2021

Lead researcher : Caroline Arbour
Co-researchers : Francis Bernard , David Williamson , Louis De Beaumont
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 1 - Consortium pour le développement de la recherche en traumatologie

Implantation des meilleures pratiques de gestion de la douleur à l'unité des soins intensifs de traumatologie: un travail d'équipe. Projet de recherche au Canada / 2018 - 2021

Lead researcher : Céline Gélinas
Co-researchers : Manon Choinière , Francis Bernard , Marc Perreault , David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 3 - Consortium pour le développement de la recherche en traumatologie

Sedatives newly prescribed following intensive care unit admission among sedative-naïve elderly patients: Understanding the risk of falls and determining targets for deprescribing (SNOW-FALL) Projet de recherche au Canada / 2018 - 2020

Lead researcher : Lisa Denise Burry
Co-researchers : David Williamson
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Agitation et délirium en traumatologie et aux soins intensifs Projet de recherche au Canada / 2016 - 2020

Lead researcher : David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Bourse de chercheur-boursier clinicien : Junior 1

PROSPECT: Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial Projet de recherche au Canada / 2016 - 2020

Lead researcher : Jennie Johnstone
Co-researchers : Emmanuel Charbonney , David Williamson
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs:

Revue systématique et méta-analyse sur les agents sédatifs en traumatisme crânien Projet de recherche au Canada / 2017 - 2019

Lead researcher : David Williamson
Funding sources: Fondation NeuroTrauma Marie-Robert
Grant programs:

Agitation et délirium en traumatologie et aux soins intensifs Projet de recherche au Canada / 2016 - 2019

Lead researcher : David Williamson
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Établissement de jeunes chercheurs Juniors 1

Traitement des hémorragies intracrâniennes chez les patients anticoagulés ayant subi un traumatisme crânien léger : Revue systématique et méta-analyse Projet de recherche au Canada / 2016 - 2018

Lead researcher : Jean Marc Chauny
Co-researchers : Martin Albert , David Williamson , Natalie Le Sage
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 4 - Consortium pour le développement de la recherche en traumatologie

Managing Pain In Collaboration in the Intensive Care Unit (MPIC-ICU): A Stepped Wedge Cluster Randomized Trial. Projet de recherche au Canada / 2016 - 2017

Lead researcher : Céline Gélinas
Co-researchers : Manon Choinière , Francis Bernard , Emmanuel Charbonney , David Williamson
Funding sources: IRSC/Instituts de recherche en santé du Canada
Grant programs: PVXXXXXX-(PJT) Subvention Projet

Interventions pharmacologiques pour le contrôle du délirium et de l'agitation suite à un traumatisme cranio-cérébral: une revue systématique de données cliniques et précliniques Projet de recherche au Canada / 2015 - 2017

Lead researcher : David Williamson
Co-researchers : Francis Bernard , Emmanuel Charbonney , Jean François Giguère , Marc Perreault , Anne Julie Frenette , François Lamontagne , Leslie Burry , Marie-Julie Potvin
Funding sources: FRQS/Fonds de recherche du Québec - Santé (FRSQ)
Grant programs: PVXXXXXX-Volet 4 - Consortium pour le développement de la recherche en traumatologie

Publications Expand all Collapse all

Publications des 4 dernières années:

  1. Cataford G, Monton LA, Karzon S, et al. Cognitive and motor function effects of antipsychotics in traumatic brain injury: a systematic review of pre-clinical studies. Neurotrauma Reports 2024:5(1):181–193.
  2. El-Hattaf I, Marsot A, Hachemi D, Pesout T, Williams V, Smith MA, Albert M, Williamson D. Exposure Levels and Target Attainment of Piperacillin/Tazobactam in Intensive Care Unit Adult Patients: a Prospective Observational Study. Can J Anesth 2024;ePub Jan 19th.
  3. Saavedra-Mitjans M, Frenette AJ, McCredie V, Arbour C, Charbonney E, Albert M, Mehta S, Wang HT, Burry L, Bernard F, Williamson D. ICU physicians’ beliefs and perceived importance of agitation in TBI patients: A survey of Canadian intensivists. Can J Anesth 2024;71:264-73.
  4. White G, Adessky N, Chen FW, Regazzoni A, Tourian L, Chagnon M, Gursahaney A, Roux M, Alharbi M, Williamson D, Perreault. Impact Of Valproic Acid For Agitation In The Intensive Care Unit: a Retrospective Analysis Of Psychiatric Consults. Int J Clin Pharm 2024;1:177-85.
  5. Leclerc C, Gervais C, Hjeij D, Briand MM, Williamson D, Bernard F, Duclos C, Arbour C. Sleep in hospitalized adults sustaining a traumatic brain injury: A scoping review. J Head Trauma Rehab 2023;ePub 28 sept
  6. D’Amours M, Ettis F, Ginefri L, Lim J, Lin Poo Yuan A-S, Fontaine J, Wazzan D, Williamson D, Dagenais-Beaulé V. A pilot study to improve geriatric care through a pharmacist-led psychotropic stewardship program. Drugs and Aging 2023; 40:1037-1045.
  7. El-Hattaf I, Laverdière J, Albert M, Marsot A, Williamson D. Potential Benefits of Therapeutic Drug Monitoring for Beta-lactam Antibiotics in Augmented Renal Clearance Patients: A Case Report. Canadian Journal of Physiology and Pharmacology 2023;102:69-74.
  8. Daoust R, Paquet J, Marquis M, Williamson D, Fontaine G, Chauny JM, Frégeau A, Orkin A, Cournoyer A. Efficacy and Safety of Prescribed Opioids for Acute Pain after Being Discharged from the Emergency Department: A Systematic Review. 30:1253-1263.
  9. Duceppe MA, Kanji S, Ruo N, Do A, Cavayas YA, Robert-Halabi M, Albert M, Zavalkoff S, Samoukovic G, Williamson DR. Alterations in the pharmacokinetics and pharmacodynamics of commonly used antimicrobials in pediatric critical care patients during extracorporeal membrane oxygenation: A systematic review. Pediatric Drugs 2023;25:515-535
  10. Daoust R, Paquet J, Chauny JM, Williamson D, Huard V, Arbour C, Emond M, Rouleau D, Cournoyer A. Impact of Vitamin C on the Reduction of Opioid Consumption After an Emergency Department Visit for Acute Musculoskeletal Pain: A Double-Blind Randomized Control Trial Protocol. BMJ Open 2023;13:e699230.
  11. Kanji S, Williamson D, Hartwick M. Pharmacological confounders in the setting of brain death declaration. Can J Anesth 2023;70:713-23.
  12. Beaucage-Charron J, Rinfret J, Coveney R, Williamson D. Melatonin and Ramelteon in the Treatment of Delirium: A Systematic Review and Meta-analysis. J Psychomatic Res 2023;170:111345.
  13. Ouerd S, Frenette AJ, Williamson D, Serri K, D’Aragon F, Meade M, Bichet D, Charbonnney E. Vasopressin use in organ donors: a narrative review of the literature and evidences. Crit Care Explorations 2023;5:e0907
  14. Flynn F, Dobrescu MA, Richard G, Hassan C, Pigeon M, Chagnon M, Charbonney E, Serri K, D’Aragon F, Weiss MJ, Williamson DR, Frenette AJ. Self-perceived role and knowledge of community pharmacists in organ donation. Int J Clin Pharm 2023;45:748-57.
  15. Duquet-Armand M, Bouziane A, Arruda A, Denault JS, Routhier A, Cusson T, Halwagi A, Williamson D, Perreault M, Lordkipanidzé, Létourneau-Guillon L, Thiboutot Z. Spontaneous intracranial hemorrhage and oral anticoagulation: a retrospective study. Can Journ Gen Int Med 2023;18:54-65.
  16. Duong A, Simard C, Williamson D, Marsot A. Tobramycin a priori dosing regimens based on PopPK model’s simulations in critically ill patients: are they transferable? Ther Drug Monit 2023;45:616-622
  17. Dionne JC, Johnstone J, Heels-Ansdell D, Duan E, Lauzier F, Arabi YM, Adhikari NKJ, Sligl W, Dodek P, Rochwerg B, Marshall JC, Niven DJ, Williamson DR, Reynolds S, Zytaruk N, Cook D.Clostridioides Difficile Infection in Mechanically Ventilated Critically Ill Patients: A Nested Cohort Study. J Crit Care 2023; 75:154254.
  18. Burry LD, Bell C, Hill A, Pinto R, Scales DC, Bronskill SE, Williamson D, Rose L, Fu L, Fowler R, Martin CM, Dolovich L, Wunsch H. New and persistent sedative prescription after critical illness among older adults: A population-based cohort study. Chest 2023;163:1425-36.
  19. Hardy A, Beetz G, Chamali K, Courgeon M, Sandman E, Williamson D, Goetti P, Leduc S, de Beaumont L, Rouleau DM. Traumatic Brain Injuries in Proximal Humeral or Clavicle Fractures Studies: The Missing Link – A Systematic Review. International Orthopedics 2023;47:17-50.
  20. Daoust R, Paquet J, Williamson D, Perry J, Iseppon M, Castonguay V, Morris J, Cournoyer A. Accuracy of a Self-Report Prescription Opioid Use Diary for Patients Discharge from the Emergency Department with Acute Pain. BMJ Open 2022;12:e062984.
  21. Duong A, Simard C, Williamson D, Marsot A. Model re-estimation: an alternative for poor predictive performance during external evaluations? Example of gentamicin in critically ill patients. Pharmaceutics 2022 ;14:1426.
  22. Marsolais P, Larouche G, Lagacé AM, Williams V, Bernard F, Rico P, Frenette AJ, Williamson D, Albert M, Charbonney E. The feasibility of potential organ donors using real case-scenarios; do we need to create a “donor board” process for donors perceived as unlikely feasible? Transplant Intl 2022;35:10107.
  23. Duong A, Simard C, Williamson D, Thirion D, Marsot A. Aminoglycosides’ dosing and monitoring practices in intensive care unit settings in Quebec. J Chemother 2022; 34:341-44.
  24. Chan C, Burry L, Tse C, de Castro C, Wunsch H, Williamson D. Impact of ketamine analgosedation on outcomes in critically ill patients: Systematic review and meta-analysis. Ann Pharmacother 2022; 56:1139-1158
  25. Daoust R, Paquet J, Marquis M, Chauny JM, Williamson D, Huard V, Arbour C, Émond M, Cournoyer A. Evaluation of Interventions to Reduce Opioid Prescribing for Patients Discharged From the Emergency Department: A Systematic Review and Meta-analysis. JAMA Netw Open. 2022;5(1):e2143425.
  26. Martineau-Lessard, C., Arbour, C., Germélus, N-É., Williamson, D., De Beaumont, L., Bernard, F. Pupil light reflex for the assessment of analgesia in critically ill sedated patients with traumatic brain injury: A preliminary study. Journal of Neuroscience Nursing 2022;54:6-12.
  27. Daoust R, Paquet J, Huart V, Chauny JM, Lavigne G, Williamson D, Choiniere M, Lang E, Yan JW, Perry JJ, Emond M, Gosselin S, Cournoyer A. Association Between Fentanyl Treatment for Acute Pain in the Emergency Department and Opioid Use Two Weeks After Discharge. Am J Emerg Med 2022;52:137-142.
  28. Johnstone J, Meade M, Lauzier F, Marshall J, Duan E, Dionne J, Arabi Y, Heels-Ansdell D; Thabane L, Lamarche D; Surette M; Zytaruk N, Mehta S, Dodek, P, Mcintyre L, English S; Rochwerg B,Karachi T, Henderson W, Wood G, Ovakim D, Herridge M, Granton J, Wilcox E, Gioffi A, Stelfox H; Niven D, Muscedere, J, Lamontagne F, D'Aragon, F, St-Arnaud C, Ball I, Nagpal D, Girard M, Aslanian P, Charbonney E, Williamson D, Sligl W, Friedrich J, Adhikari N; Marquis F, Archambault P, Khwaja K, Kristof A, Kutsiogiannis J, Zarychanski R, Paunovic, B, Reeve B, Lellouche F, Hosek P, Tsang J, Binnie A, Trop S, Loubani O, Hall R, Cirone R, Reynolds S, Lysecki P, Golan E, Carten Ceba R, Taylor R, Cook D. Lactobacillus Rhamnosus GG in Critical Illness: A Randomized Trial. JAMA 2021;326:1024-33.
  29. Burry L, Chen W, Williamson D, Guenette M, Hutton B, Mehta S, Egerod I, Kanji S, Adhikari NK, Moher D, Martin C, Rose L. Intensive Care Med 2021;47:943-60.
  30. Saavedra Mitjans M, David PM, Frenette AJ, Arbour C, Perreault MM, Williams V, Bernard F, Williamson DR. EXperienceS and aTtitudes towards Agitated behaviors in Tbi ICu patients (EXSTATIC): a protocol for an interprofessional mixed-method study. BMJ Open 2021; 11:e045816
  31. Duceppe MA, Kanji S, Ruo N, Do A, Cavayas YA, Robert-Halabi M, Albert M, Zavalkoff S, Samoukovic G, Williamson DR. Alterations in the pharmacokinetics and pharmacodynamics of commonly used antimicrobials in critical care patients during extracorporeal membrane oxygenation: A systematic review. Drugs. 2021;81:1307-1329.
  32. Morris JL, Bernard F, Bérubé M, Dubé JN, Houle J, Laporta D, Morin SN, Perreault M, Williamson D, Gélinas C. Determinants of Pain Assessment Documentation in Intensive Care Units. Can J Anaesth. 2021;68:1176-1184
  33. Duong A, Simard C, Wang YL, Williamson D, Marsot A. Aminoglycosides in the intensive care unit: what’s new in population PL modeling. Antibiotics (Basel) 2021;10:507.
  34. Williamson DR, Kanji S, Burry LD. Advanced Pharmacist Practitioner Series – Clinician scientist. Can J Hosp Pharm 2021;74:130-4.
  35. Bilodeau V, Saavedra Mitjans M, Frenette AJ, Burry L, Albert M, Bernard F, Williamson DR. . J Clin Pharm Ther 2021;46:1020-26.
  36. Bendayan M, Mardigyan V, Williamson D, Chen-Tournoux A, Eintracht S, Rudski L, MacNamara E, Blostein M, Afilalo M, Afilalo J. Association of Muscle Mass With Direct Oral Anticoagulant Activity in Older Adults. J Am Geriatr Soc 2021;69:1012-1018.
  37. Williamson DR, Cherifa S, Saavedra Mitjans M, Arbour C, Frenette AJ, Charbonney E, Blais L, Burry LD, Mehta S, Bernard F. A pilot feasibility cohort study of agitated behaviors in critically traumatic brain injury patients. Pilot and feasibility Studies 2020;6:193.
  38. Gagnon A, Laroche M, Williamson DR, Giguère JF, Giroux M, Bernard F. Incidence and characteristics of cerebral hypoxia after craniectomy in brain injured patients: a cohort study. J Neurosurgery 2020;135 :554-61.
  39. Flynn F, Richard G, Dobrescu MA, Bouchard J, Williamson DR, Brindamour D, Charbonney E, Dupuis S. Refractory dabigatran-induced hemorrhage despite multiple idarucizumab administration and renal replacement therapy. J Pharm Pract 2022;35:302-07.
  40. Frenette AJ, Williamson DR, Rochwerg B, Weiss MJ, Ball I, D’Aragon F, Serri K, Brindamour D, Meade M, Charbonney E.Worldwide management of donors after neurological death: a systematic review and narrative synthesis of guidelines. Can J Anesth 2020;67:1839-1857
  41. Cavayas YA, Noël A, Brunette V, Williamson DR, Bellemare P, Lagrenade-Verdant C, LeGuillan S, Levesque E, Frenette AJ, Lamarche Y, Giasson M, Rico P, Beaulieu Y, Marsolais P, Serri K, Bernard F, Albert M. Early experience with critically ill patients with COVID-19 in Montreal. Can J Anaesth. 2021;68:204-213.
  42. Burry LD, Barletta J, Williamson D, Kanji S, Maves RC, Dichter J, Christian MD, Geiling J, Erstad B. Chest. 2020;158:2414-2424
  43. Jutras M, Williamson DR, Chassé M, Leclair G. Development and validation of a liquid chromatography coupled to tandem mass spectrometry method for the simultaneous quantification of five analgesics and sedatives, and six of their active metabolites in human plasma: Application to a clinical study on the determination of neurological death in the intensive care unit. J Pharm Biomed Anal. 2020;190:113521
  44. Sneyers B, Duceppe MA, Frenette AJ, Burry LD, Rico P, Lavoie A, Gélinas C, Mehta S, Dagenais M, Williamson DR, Perreault MM Drugs 2020 26:1-23.
  45. Kanji S, Burry L, Williamson D, Pittman M, Dubinsky S, Patel D, Natarajan S, MacLean R, Huh JH, Scales D, Neillipovitz D. Therapeutic Alternatives and Strategies for Drug Conservation in the ICU During Times of Drug Shortage. Can J Anesth. 2020;67:1405-1416
  46. Sokoloff C, Williamson D, Serri K, Albert M, Odier C, Charbonney E and Bernard F. Clinical Usefulness of Transcranial Doppler as a Screening Tool for Early Cerebral Hypoxic Episodes in Patients with Moderate and Severe Traumatic Brain Injury. Neurocritical Care 2020;32:486-91.
  47. Frenette AJ, Williamson DR, Williams V, Lagacé AM, Charbonney E Serri K. Efficacy and safety of levothyroxine on cardiac function in brain dead organ donors: a pilot study. Prog Transplant 2020;29:261-268.
  48. Daoust R, Paquet J, Cournoyer A, Piette E, Morris J, Lessard J, Castonguay V, Williamson D, Chauny JM. Opioid Induced Side Effects, Including Constipation, For The Acute Pain of Emergency Department Discharged Patients. Am J Emerg Med 2020;38:695-701

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